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Over a quarter of the Indian adult population is either obese, at risk of diabetes or are diabetic. This has become a marketing & business opportunity for a lot of fitness & healthtech companies with plain vanilla no science interventions focussed on either high protein, calorie counting, CGM driven or at worst GLP-1 drugs. But these companies fail to understand how human biochemistry works. These interventions, if they help in weight loss, is a stop gap arrangement. Weight gain is not the cause but the effect & symptom. Obesity is triggered by low grade chronic inflammation & our body tries its best to maintain a metabolic homeostasis. However, regular insults we do to our body by consuming toxins or ingesting those foods that are transformed by your microbiome into toxins or pro-inflammatory metabolites makes it hard for us to lose weight. Some of these metabolites include LPS, TMAO, P-cresol & more. While microbes living in our mouth & gut also produce certain beneficial metabolites & incretin hormones ( providing we are feeding them with the right food substrates) that maintain our metabolic health & make it hard for us to gain weight. One of the most important metabolites ( incretin hormone) is GLP-1. Yes, our body automatically produces GLP-1 by synthesising fibre & polyphenols in the food we eat. GLP-1 has multiple benefits via regulating various metabolic pathways-regulates blood sugar response, communicates with brain via gut-brain axis , telling that you are full & even tells stomach & intestine to slow the movement of digestive tract. However, these GLP-1 drugs which lot of companies claim mimics natural GLP-1 brings multiple side effects & just ingesting these drugs does not mean it will help you lose weight. -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs . -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help. -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. We at Genefitletics measures these pathways to construct nutritional therapeutics interventions aligned with your biochemistry that reinstates yout metabolic homeostasis Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC4112002/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://pmc.ncbi.nlm.nih.gov/articles/PMC10391832/ https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC5082693/ #obesity #obesityfreeindia #obesityfreenation #obesityawareness #viralvideo #virlshort #viralreels #viral_video #viralshorts #viralnews #healthnews #healthtips #health #healthylifestyle #supplements #obesitymedicine #obesityprevention #obesityawareness #type2diabetes #diabetesawareness #diabetesmanagement #diabetescare #diabetescure
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Are supplements the missing piece in your weight loss journey? Let’s settle this once and for all. Here’s the deal: losing weight isn’t just about eating salads and hitting the gym. It’s about tackling metabolism, hormones, and energy production at their core. And guess what? The right supplements can make a BIG difference. 👇 1️⃣ Green Tea Extract: Turns up your metabolism and helps burn fat—yes, even when you’re chilling. 2️⃣ Protein Supplement*: Keeps you full, helps build muscle (which burns more calories), and supports recovery. 3️⃣ Magnesium: Balances blood sugar, improves sleep and energizes your cells for better calorie burn. ✨ 4️⃣ Omega-3s: Cuts inflammation, helps release stored fat and improves heart health. 🐟 5️⃣ Creatine: Powers your workouts, boosts recovery, and supports lean muscle growth for more calorie burn. 🔋 6️⃣ Berberine: A metabolism hero—balances insulin, increases energy, and helps you burn fat efficiently. 🌿 Supplements aren’t shortcuts, but they ARE powerful tools when paired with good habits. 💬 Which of these supplements have you tried? Let’s chat in the comments!
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Joe Rogan shares his thoughts on a case for Social Funding & Competition in this clip from the Joe Rogan Experience (JRE). His take on this subject is thought-provoking and worth discussing. Watch this Joe Rogan Podcast clip and share your thoughts in the comments. Don’t forget to like, comment, and subscribe for more JRE Clips and trending content. Turn on notifications so you never miss an update. #shorts #joerogan #joeroganexperience #jre #health #funding #interesting #podcast #competition Keywords: Joe Rogan, Joe Rogan Experience, JRE, Joe Rogan Podcast, JRE Clips, podcast clips, Joe Rogan Shorts, trending shorts, viral clips, MMA, UFC, Elon Musk, AI, motivation, stand-up comedy, conspiracy theories.
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