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What are the side effects of CBD, and how do they affect you? Dr. Debbie discusses what they could be. Visit Three Wells now for more info on CBD or cannabis: https://www.threewells.co/learn-home/ Want to understand more about CBD and cannabis? Here's a great starter guide: https://www.threewells.co/article/a-consumers-guide/ Subscribe for more videos from Three Wells: https://www.youtube.com/channel/UCm94 About Three Wells' Dr. Debbie Deborah Malka MD, PhD is a physician specializing in cannabis medical consultations in the Central Coast of California. Prior to clinical practice, Dr. Debbie completed her PhD in Human Genetics from Columbia University, and studied both natural and traditional medicine, with degrees from the University of New Mexico School of Medicine and the Santa Fe College of Natural Medicine. She is both a clinician and an educator in this specialty. She has previously served as the medical director for MediCann Inc., a group of clinics providing medical marijuana evaluations in California, serving over 300,000 patients. She is currently the faculty director for an on-line CME accredited course in Clinical Cannabinoid Medicine sponsored by the Society of Cannabis Clinicians.
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The antibacterial properties of cannabinoids primarily operate through disruption of bacterial cell membranes, leading to rapid bactericidal effects. Key mechanisms include: Membrane disruption and depolarization: Cannabidiol (CBD) and cannabigerol (CBG) target the cytoplasmic membrane of Gram-positive bacteria such as Staphylococcus aureus and MRSA. This causes membrane depolarization, increased permeability, and uptake of normally impermeable dyes, indicating loss of membrane integrity. This disruption rapidly inhibits synthesis of proteins, DNA, RNA, and peptidoglycan, effectively shutting down essential bacterial processes. Inhibition of biofilm formation: CBG inhibits the ability of bacteria to form biofilms and can eradicate preformed biofilms, which are typically resistant to antibiotics. This enhances the antibacterial effect and helps clear persistent infections. Synergistic effects with antibiotics: CBD has been shown to enhance the efficacy of certain antibiotics like bacitracin by inducing abnormalities in bacterial cell division and membrane irregularities. Additionally, cannabinoids can work synergistically with polymyxin B to target multidrug-resistant Gram-negative bacteria when their outer membrane is permeabilized. Selective activity against Gram-positive and some Gram-negative bacteria: Cannabinoids are most effective against Gram-positive bacteria due to easier access to the cytoplasmic membrane. However, cannabinoids like CBD and CBG can also act on Gram-negative bacteria with permeabilized outer membranes, including drug-resistant strains such as Neisseria gonorrhoeae. Structure-activity relationship: The antibacterial potency of cannabinoids is influenced by their chemical structure, including the monoterpene region and aromatic side chains, which affect their lipid affinity and membrane interaction. In summary, cannabinoids exert antibacterial effects mainly by disrupting bacterial membranes, inhibiting biofilm formation, and enhancing antibiotic activity, making them promising candidates for new antimicrobial therapies especially against resistant Gram-positive pathogens Join this channel to get access to perks: https://www.youtube.com/channel/UC23aSgHY8WaJGw4nft7Sn7g/join
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Join John and his guest, Dr. Nigam Arora, in this fascinating conversation about what the future holds for cannabis products and consumers. Dr. Nigam Arora is an accomplished PhD chemist with an interest in translation of plant to accepted medicine. He is young and gives hope to all those who benefit from the use of cannabis through the application of chemical standards to the plant. This will make cannabis users feel justified in their knowledge that this super herb is beneficial to the human race and ultimately, and for our basic health needs should be re-introduced to our food source and hopefully available as a specially dosed, treatment. Visit us at: https://www.unitedpatientsgroup.com Follow our Podcast: https://www.buzzsprout.com/1129859 Follow us on Twitter: https://www.twitter.com/upatientsgroup Facebook: https://www.facebook.com/UnitedPatientsGroup/
