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This episode I discuss the hormones testosterone and estrogen and how they impact the brain, body, and behavior at ages after puberty. I also discuss how various behaviors such as exercise (resistance and endurance training) and sex, or observing sex impact these hormones and their levels. I ask: "what specifically is it about such activities that impact testosterone and estrogen?"; the resounding theme is that when our nervous system is activated in particular ways it drives our endocrine system and vascular system to activate or repress certain hormone networks in predictable ways. I also discuss peer-reviewed studies and protocols addressing (at a mechanistic level) how light, cold and heat, and respiration (breathing) can positively or negatively impact testosterone and estrogen. And we discuss specific supplements and compounds that peer-reviewed studies illustrate can adjust testosterone and estrogen levels: by changing their binding to other proteins, by raising them directly, or by changing other hormones released from the brain and pituitary. I discuss optimization in the normal reference ranges for these hormones, and I discuss pheromones, apnea, menstrual cycles, menopause and andropause. As always a mix of basic science, biological mechanisms and tools and protocols are discussed. **Note: Future episodes will focus on the science of prescription hormone replacement therapies, the science of hormone-based birth control and the role of testosterone, estrogen and other compounds in fertility, athletic performance and recovery. #HubermanLab #Testosterone #Estrogen Thank you to our sponsors Four Sigmatic - https://foursigmatic.com/huberman Blinkist - https://blinkist.com/huberman Theragun - https://theragun.com/huberman Bloodwork sponsor InsideTracker - https://insidetracker.com/huberman Supplements from Thorne http://www.thorne.com/u/huberman Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network References: Examine: https://examine.com “Behavioral Endocrinology” by Nelson and Kriegsfeld 5th Ed. Timestamps 00:00:00 Introduction 00:05:50 Hormone Optimization 00:07:00 Salutogenesis: A Powerful Way to Conceptualize Health 00:10:03 Estrogen and Testosterone: Sources, Levels & Ratios 00:15:46 The Power of Competition, Plus: Anxiety, Persistence & Dopamine 00:20:58 Testosterone & Libido Pre-Ovulation 00:21:48 Estrogen & Sexual Receptivity; Libido In Males 00:23:10 How Sex Behavior Impacts Testosterone: Observing vs. Actual vs. Abstinence 00:26:46 Testosterone & Prolactin: Sex Seeking vs Pair Bonding 00:27:30 DHEA (dehydroepiandrosterone): Effects on Levels/Ratios 00:28:45 Behaviors That Decrease Testosterone (& Cortisol): Parenting & Prolactin 00:31:24 How Illness Impacts Testosterone & Estrogen: Cytokines, e.g., IL-6 00:33:20 How Exactly Do Behaviors Change Hormones? 00:34:18 Pheromones: Miscarriage, Menstrual Cycles, Puberty Onset, & Mate Recognition 00:43:33 Apnea: A Powerful Bi-Directional Influence On Estrogen & Testosterone 00:47:44 Mouth vs. Nose Breathing & Hormone Levels: Effects Via Sleep and Direct Effects 00:51:11 How Sleep Adjusts Cortisol/Testosterone and Cortisol/Estrogen Ratios 00:53:49 02:CO2 Ratios, Nasal Breathing During Exercise 00:56:30 Light Viewing Patterns & Hormones: Dopamine, GnRH 00:57:44 Spring Fever: Tyrosinase, Hair Color, Mating Frequency 01:04:39 Specificity of Hormone Effects 01:06:03 Temperature: Cold & Hot Gonads 01:14:10 How To Exercise: Types, Effort Level, Sequencing 01:21:42 Cardio/Endurance vs. Resistance Training (First or Last?) Yes, It Matters 01:24:41 Estrogen & Menopause: Compounds That May Ameliorate/Reverse Symptoms 01:33:18 Nutrients That Optimize The Foundation For Hormones 01:36:00 Opioids as Severe Hormone Disruptors 01:37:23 Testes, Antlers & Ovaries 01:38:50 Creatine & Increasing DHT (Dihydrotestosterone) 01:40:14 Free and Bound Testosterone: SHBG (Sex Hormone Binding Globulin), Tongat Ali 01:43:23 Nettles, Prostate, Boron, & Blood Brain Barrier 01:45:27 Hormone Related Cancers: Sometimes Reducing Estrogen and Testosterone Is Optimal 01:47:43 Ecdysteroids: Mimic Mammalian Hormones 01:51:50 Optimizing Brain Hormones: Chorionic Gonadatropin, Fadogia Agrestis 01:57:18 Additional Compounds, Liver Toxicity, Overall Milieu 01:59:17 Summary: And Note About Additional Related Topic Coverage Coming Disclaimer: https://hubermanlab.com/disclaimer/ Title Card Photo Credit: Mike Blabac https://www.blabacphoto.com
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Research Evidence Supporting Weight Loss
A recent clinical trial conducted on Semaglutide showed remarkable results in promoting weight loss among participants. The study, published in the New England Journal of Medicine, reported an average weight loss of over 15% among individuals who received Semaglutide compared to the placebo group. Furthermore, those who took Semaglutide also experienced improvements in blood sugar levels and a reduced risk of developing obesity-related health conditions.
Potential Side Effects and Considerations
Like any medication, Semaglutide may cause side effects in some individuals. Common side effects include nausea, vomiting, diarrhea, and constipation. It is essential to consult with a healthcare provider before starting Semaglutide to assess its suitability for your individual health needs. Additionally, Semaglutide is not recommended for pregnant women, individuals with a history of pancreatitis, or those with a personal or family history of medullary thyroid carcinoma.
Combining Semaglutide with Lifestyle Changes
While Semaglutide can be a valuable tool in weight loss efforts, it is essential to incorporate healthy lifestyle changes for long-term success. This includes adopting a balanced diet rich in fruits, vegetables, lean proteins, and whole grains, as well as engaging in regular physical activity. A holistic approach that combines Semaglutide with healthy habits can maximize weight loss results and improve overall well-being.
Consulting with a Healthcare Provider
Prior to starting any weight loss medication, including Semaglutide, it is crucial to consult with a healthcare provider. A medical professional can evaluate your specific health concerns, review your medical history, and determine if Semaglutide is a safe and appropriate option for you. They can also provide guidance on dosage, potential side effects, and monitoring your progress throughout treatment.
Summary and FAQ
In conclusion, Semaglutide has shown promising results in aiding weight loss and improving metabolic health in individuals struggling with obesity. By understanding how Semaglutide works, considering potential side effects, combining it with lifestyle changes, and consulting with a healthcare provider, individuals can make informed decisions about incorporating Semaglutide into their weight loss journey. For more information on Semaglutide and its use for weight loss, refer to the following frequently asked questions:
Q: How long does it take to see results with Semaglutide?
Q: Can Semaglutide be used for long-term weight maintenance?
Q: What should I do if I experience side effects while taking Semaglutide?
Q: Are there any dietary restrictions while taking Semaglutide?
Q: Is Semaglutide covered by insurance for weight loss purposes?
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