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While looking over the research on the effect of GLP-1 receptor agonists on alcohol consumption, I stumbled across a recent and _really_ interesting paper on how that class of drugs affects sensation. It's "Glp-1 Receptor Agonists Significantly Impair Taste Function" by Rafa Khan and Richard L. Doty in _Physiology & Behavior_ Vol. 291 (published version at https://www.sciencedirect.com/science/article/abs/pii/S003193842400341X and white paper version at https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4953499 ). Don't necessarily take that title on its face, as the details are super important and incredibly interesting and maybe not as dire as you'd think. And, well, I felt like it would be a good use of my platform to discuss all of this. So that's what we're doing today, talking about this hugely consequential new class of drugs - Wegovy/Ozempic (semaglutide), Mounjaro (tirzepatide, although that's also a GIP), and whatever else is going to be out there - with an eye towards spirits nerdery. First I broadly discuss the history and basic mechanisms of these drugs, with a brief detour into side effects and what I would consider to be "best practices" in using them for weight loss purposes. (N.b., I don't get into treatment for type 2 diabetes and that's another set of concerns, also I am not a doctor and please consult a medical professional for all this etc..) And then I discuss the paper above. And... well, it's complicated. Based on their results I think the main takeaway is that while GLP-1 agonists seem to have very good odds of degrading your sense of taste, there's also pretty good odds that you won't actually notice. 🤷 Extra special thanks to my Different Spirits on Patreon (https://www.patreon.com/differentspirits), who got this video first - Eric Amig Anthony Darcy Bean Jamie Brown Kingsbury bushcraft William Christopher Clematis Rob D Liam Davitt Joe Devine Samuel Dose Stephen Eckert eon Ingmar nine Steve Frazee Ian Gendler Solomon Grundy John Halliday Alex Hurd Trevor Jarrait Jonathan Lestingi Kyaru Ariel Mserious Craig Nielsen Jason Newquist No Thanks Chris Rhodes Randy Rice RumSquirrel Gordon W Zach W
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🎯 I tried EVERYTHING. Nutrition, training, supplements… all the things. But no matter how hard I worked, my body wasn’t responding. 😩 💡 Then my homeopathic doctor recommended GLP-1s. At first? I was totally against it. 🚫 I thought, "No way. That’s not for me." 🔬 But I did the research. I learned how it works with my metabolism, not against it. And guess what? It’s the BEST decision I’ve made. 🔥 13 pounds down in 6 weeks and I feel amazing! More energy, better digestion, and most importantly—I finally feel like my body is working with me, not against me. 💪✨ 👉 If you’ve been struggling despite doing all the “right” things, you’re not alone. Drop "NOW" in the comments or DM me to chat! 💬💙 #GLP1Journey #WeightLossTransformation #PeptidePower #GLP1Results #MetabolicHealth #FatLossJourney #HormoneBalance #WellnessOver40 #MidlifeWeightLoss #HealthyAging #LongevityLifestyle #WomenOver40 #BiohackingWomen
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When it comes to weight loss, there are various medications and treatment options available on the market. Two of the most popular options currently are Semaglutide and Tirzepatide. Both of these medications are known for their effectiveness in helping individuals lose weight, but how do they compare to each other? In this article, we will delve into a comparative study of Semaglutide vs Tirzepatide for weight loss, examining their mechanisms of action, side effects, and overall effectiveness in helping individuals achieve their weight loss goals.
Mechanisms of Action
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of GLP-1 in the body. GLP-1 is a hormone that is released in response to food intake and helps regulate blood sugar levels. By activating the GLP-1 receptors, Semaglutide can help reduce appetite, increase feelings of fullness, and slow down gastric emptying, leading to reduced calorie intake and weight loss.
On the other hand, Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. GIP is another hormone that is released in response to food intake and plays a role in regulating insulin secretion and glucose metabolism. By targeting both GIP and GLP-1 receptors, Tirzepatide has the potential to provide additional benefits in terms of weight loss and glycemic control compared to Semaglutide.
Side Effects
Like all medications, Semaglutide and Tirzepatide come with a risk of side effects. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild and may improve over time as the body adjusts to the medication. In some cases, Semaglutide may also cause pancreatitis or gallbladder problems.
On the other hand, common side effects of Tirzepatide include nausea, vomiting, diarrhea, and abdominal pain. These side effects are similar to those of Semaglutide and are generally well-tolerated. However, there is some evidence to suggest that Tirzepatide may have a higher risk of hypoglycemia compared to Semaglutide, especially in individuals with diabetes.
Effectiveness
Both Semaglutide and Tirzepatide have been shown to be effective in helping individuals lose weight. Clinical trials have demonstrated that Semaglutide can lead to significant weight loss, with some individuals achieving weight reductions of over 15% of their initial body weight. Tirzepatide has also shown promising results in clinical trials, with some studies reporting even greater weight loss compared to Semaglutide.
It is important to note that individual responses to medication can vary, and not everyone will experience the same level of weight loss with Semaglutide or Tirzepatide. Factors such as diet, exercise, and overall health can all influence the effectiveness of these medications in helping individuals achieve their weight loss goals.
Conclusion
In conclusion, both Semaglutide and Tirzepatide are effective options for individuals looking to lose weight. While Semaglutide has been well-established as a weight loss medication, Tirzepatide shows promise as a dual GIP and GLP-1 receptor agonist with the potential for additional benefits. Ultimately, the choice between Semaglutide and Tirzepatide will depend on individual preferences, health considerations, and the guidance of a healthcare provider.
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Unlock your fitness potential with these key strategies! In this video, we dive deep into the essentials for achieving your fitness goals. Discover why consistency is crucial and why you should aim for 3 to 5 intense workouts each week. Learn the importance of a balanced diet packed with clean, high-protein meals and tips to reduce sugar and processed foods. Track your progress effectively with measurements and photos, and understand that patience is key, as results typically take 6 to 12 weeks. If you find these tips helpful, don't forget to like and share the video! #FitnessJourney #HealthyLiving #WorkoutMotivation #BalancedDiet #FitnessGoals
