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0:00 Ayds 1:15 Dinitrophenal 3:42 Rainbow Diet Pills 5:47 Orlistat 6:30 GLP-1 drugs Sources: Ayds https://en.wikipedia.org/wiki/Ayds DNP https://www.astralcodexten.com/p/shilling-for-big-mitochondria https://pmc.ncbi.nlm.nih.gov/articles/PMC3550200/ https://www.wearethemighty.com/mighty-history/drug-russians-took-beat-nazis/ Rainbow Diet Pills https://pmc.ncbi.nlm.nih.gov/articles/PMC3482033/ https://pharmrev.aspetjournals.org/article/S0031-6997(24)01271-7/fulltext Orlistat https://en.wikipedia.org/wiki/Orlistat Semaglutide https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases https://medicine.uq.edu.au/article/2024/04/rise-ozempic-how-surprise-discoveries-and-lizard-venom-led-new-class-weight-loss-drugs https://mcpress.mayoclinic.org/living-well/health-benefits-of-semaglutide-beyond-weight-loss/
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Embark on a journey through the intricate world of Ghrelin, Leptin, and GLP-1 in this gut health and hormone episode! Wondering what on earth they do and if it's worth knowing? Spoiler alert: it is! Ghrelin: Your Body's Dinner Bell Meet Ghrelin, the dinner bell hormone that signals your brain, "Time to eat!" Learn how managing this hunger maestro can help you understand when you're truly hungry or just bored. Leptin: The Appetite Superhero Discover the superhero that says, "I'm full, put the fork down!" Leptin works hand in hand with Ghrelin, but sometimes its signals need a bit of translation. We'll coach you on maintaining a healthy relationship with this appetite regulator. GLP-1: The Meal Satisfaction Maestro GLP-1, the maestro orchestrating harmony between digestion, satiety, and blood sugar control. Find out how it slows stomach emptying, keeping you satisfied, and explore the buzz around GLP-1 inhibitor drugs. Balancing Act: Your Backstage Pass Naturally balance these hormones with mindful eating, quality sleep, regular exercise, and embracing fiber-rich foods. No magic fixes, just a symphony of lifestyle habits for lasting wellness. Decision Time: GLP-1 Inhibitors Thinking about GLP-1 inhibitors? Before you dive in, understand the positives and negatives. Focus on building healthy muscle and changing your diet for long-term success. Ready for a rhythm of wellness? Hit play and let's groove to the beat of these hormone maestros! If you find the info helpful, leave a review and share the podcast for others to join the symphony of health. Related Episodes: https://holistichealthmadesimple.com/gut-health-and-hormones/ https://holistichealthmadesimple.com/importance-of-muscle-mass/ https://holistichealthmadesimple.com/hunger/ Holistic Health Coaching can be found - https://holistichealthmadesimple.com/services/ Join the newsletter - https://holistichealthmadesimple.com/ (https://holistichealthmadesimple.com/glucose-rollercoaster/) Leave me a message - - - https://www.speakpipe.com/HolisticHealthMadeSimple In listening to this podcast you are agreeing to the DISCLAIMER - you can read it at https://holistichealthmadesimple.com/disclaimer/
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: Hello, healthcare heroes! The landscape of type 2 diabetes management has been significantly impacted by two powerful injectable medications as per Primary FDA Indication (: Ozempic from Novo Nordisk and Mounjaro from Eli Lilly. Let's break down their differences and strengths. Both Ozempic and Mounjaro are incretin mimetics, leveraging natural gut hormones. • Ozempic® (Semaglutide) is a GLP-1 Receptor Agonist. It mimics Glucagon-Like Peptide-1, helping to lower blood sugar by stimulating insulin release when needed, slowing gastric emptying, and reducing glucagon secretion. Ozempic is available in pre-filled pens that deliver doses of 0.25 mg, 0.5 mg, 1 mg, and 2 mg per injection, with varying solution concentrations. • Mounjaro® (Tirzepatide) takes a unique approach as a dual GLP-1 and GIP Receptor Agonist. By mimicking both GLP-1 and Glucose-Dependent Insulinotropic Polypeptide, it offers potentially more comprehensive effects on blood sugar control. • Mounjaro is available as a subcutaneous injection in pre-filled single-dose pens with strengths of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL. So, how do they stack up in managing type 2 diabetes? • Blood Glucose Control: Mounjaro has shown greater effectiveness at lowering A1C levels compared to Ozempic in clinical trials, attributed to its dual mechanism. For context, the A1C goal for most non-pregnant adults with diabetes is typically less than 7%, though this is always individualized based on patient factors like age, comorbidities, and risk of hypoglycemia. • Weight Loss: While both can lead to weight loss, Mounjaro has demonstrated more significant weight loss in trials, even in type 2 diabetes patients, making it a compelling option for those with co-occurring obesity. • Cardiovascular Protection: Ozempic has established proven cardiovascular benefits, reducing the risk of major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. Mounjaro's cardiovascular outcomes are currently still being evaluated in dedicated trials Common side effects for both are predominantly gastrointestinal: nausea, vomiting, diarrhea, and constipation. These often improve with time and careful dose titration. Both carry a Boxed Warning regarding the risk of thyroid C-cell tumors, including medullary thyroid carcinoma, observed in rodent studies. They are contraindicated in patients with a personal or family history of MTC or MEN 2 syndrome (which Is a rare genetic polyglandular cancer syndrome. It is characterized by the 100% prevalence of medullary thyroid carcinoma (MTC) Pancreatitis is another serious, rare side effect. The choice between Ozempic and Mounjaro for type 2 diabetes management is highly individualized. It depends on factors like A1C goals which is a key indicator for blood glucose control in individuals with diabetes, weight management needs, cardiovascular risk, tolerability, and patient preferences. Always refer to the latest clinical guidelines and product prescribing information. Sharpen your knowledge, and as we continue exploring modern therapeutics, let's turn our attention to the exciting advancements specifically in chronic weight management... Celagen serves as a vital resource for physicians, nurses, pharmacists, and other allied health professionals seeking to deepen their understanding of advanced therapeutics. Specializing in rapidly evolving fields such as biologics and injectable medications for chronic diseases like obesity and type 2 diabetes, Celagen delivers expertly curated content designed for clarity and clinical relevance. We simplify complex scientific concepts, focusing on mechanisms of action, clinical indications, comparative effectiveness, safety profiles, and strategic considerations for patient management. Through engaging and accessible formats, Celagen aims to support HCPs in making informed decisions and optimizing patient care. #Biologics #Healthcare #MedicalEducation #HCPs #Pharmacology #Immunology #Rheumatology #Oncology #Gastroenterology #Neurology #Dermatology #Biosimilars #Celagen #MedicineExplained
