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Recently, there has been significant excitement in the medical community surrounding a new drug called Semaglutide. Originally approved by the FDA for the treatment of type 2 diabetes, Semaglutide has garnered attention for its potential off-label use as a weight loss medication. Many individuals struggling with obesity have been eager to try Semaglutide as a way to help them shed unwanted pounds. But is Semaglutide FDA approved for weight loss? Understanding the approval process can provide insight into this important question.
History of Semaglutide Approval
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was first approved by the FDA in 2017 for the treatment of type 2 diabetes. It works by mimicking the effects of a hormone produced in the intestines that helps regulate blood sugar levels. Patients with diabetes who take Semaglutide typically experience improved blood sugar control and may also see weight loss as a secondary benefit.
In 2021, Semaglutide was approved by the FDA for use in higher doses specifically for weight management in individuals with obesity or overweight who have at least one weight-related comorbidity, such as hypertension or type 2 diabetes. This approval marked a significant milestone in the fight against obesity, as Semaglutide is one of the first drugs to be approved by the FDA for this specific indication.
Mechanism of Action
Semaglutide works by activating GLP-1 receptors in the brain, which helps regulate appetite and food intake. It also slows down the emptying of the stomach, leading to a feeling of fullness that can help individuals consume fewer calories. Additionally, Semaglutide has been shown to improve insulin sensitivity and increase the body’s utilization of glucose, which can aid in weight loss and improve overall metabolic health.
Studies have demonstrated that individuals taking Semaglutide for weight management have experienced significant reductions in body weight compared to those taking a placebo. In clinical trials, participants lost an average of 15-20% of their body weight over a period of several months, making Semaglutide a promising option for individuals struggling with obesity.
Side Effects and Considerations
Like any medication, Semaglutide is not without risks. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically subside over time as the body adjusts to the medication. In rare cases, Semaglutide has been associated with more serious side effects such as pancreatitis and gallbladder disease, so it is important for individuals considering this medication to weigh the potential risks and benefits.
It is essential for individuals taking Semaglutide for weight loss to also make lifestyle changes such as adopting a healthy diet and increasing physical activity. Semaglutide is most effective when used in conjunction with a comprehensive weight management program that includes behavior modification and counseling. It is not a magic pill, but rather a tool that can support individuals in their weight loss journey.
Conclusion
In conclusion, Semaglutide is indeed FDA approved for weight loss in individuals with obesity or overweight who have weight-related comorbidities. Understanding the approval process and mechanism of action of Semaglutide can help individuals make informed decisions about whether this medication is right for them. It is important to consult with a healthcare provider before starting Semaglutide or any other weight loss medication to ensure that it is safe and appropriate for your individual health needs.
Overall, Semaglutide represents a promising option for individuals struggling with obesity, offering a new tool in the fight against this chronic and challenging condition. With proper guidance and support, Semaglutide may help individuals achieve long-term weight loss and improve their overall health and well-being.
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New Year Weight Journey and The Power of One Word Goals Hi everyone! I hope you're having a great New Year's. In this video, I talk about my weight loss journey and how I experimented with a low-calorie diet to see its impact. Despite following the same diet and exercise routine every day, my weight fluctuated, proving that weight loss isn't a straightforward process. I also discuss the concept of choosing one word to guide your New Year's resolutions and goals, instead of setting broad, unattainable goals. I share tips on breaking down big goals into smaller, actionable steps to achieve them more effectively. Join me as I dive into how I've managed to lose nearly 40 pounds and my plans for continuing a healthy lifestyle this year. Don't forget to subscribe, tell a friend, and you can always email me at jillatstartwithsmallsteps.com. Also, stay tuned for my upcoming podcast, The Bible in Small Steps, starting January 6 on YouTube. 00:00 Introduction and New Year's Greetings 00:09 Weekly Weight Loss Update 00:27 Experiment with Low-Calorie Diet 01:08 Reflections on Weight and Diet 02:58 New Year's Resolutions and Goals 03:46 The One Word Theme 08:03 Breaking Down Goals into Small Steps 11:10 Conclusion and Upcoming Plans
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📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com and/or 📢 Become an Insider, Ben’s website: https://www.benbikman.com In this Metabolic Classroom lecture, Ben challenges the conventional insulin-centric model of type 1 diabetes by introducing the “bi-hormonal hypothesis” proposed by Dr. Roger Unger. While insulin deficiency is a defining feature of T1DM, Dr. Bikman emphasizes the overlooked role of glucagon in driving hyperglycemia, ketone production, and muscle wasting. In normal physiology, insulin from beta cells locally suppresses glucagon from alpha cells. But in type 1 diabetes, this local regulation is lost, allowing glucagon to run unchecked—even when blood glucose is high. Ben explains how injected insulin, although lifesaving, can’t mimic the precise intra-islet insulin levels needed to suppress glucagon secretion. This mismatch helps explain why blood sugar control can remain elusive despite appropriate insulin use. Excess glucagon ramps up liver glucose output and ketogenesis, creating a more complex hormonal storm than insulin alone can calm. The lecture also explores new therapeutic strategies—including glucagon receptor blockers and GLP-1 agonists—that may help suppress glucagon more effectively. Dr. Bikman urges a shift in perspective: instead of seeing diabetes as just a disease of insulin, it’s time to recognize its bi-hormonal nature and tailor treatment accordingly. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, ad-free podcast episodes, show notes and references, online Office Hours access, Ben’s Research Review Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. #Type1Diabetes, #T1DM, #InsulinResistance, #Glucagon, #RogerUnger, #DiabetesScience, #MetabolicHealth, #BloodSugar, #Ketones, #DiabetesEducation, #InsulinTherapy, #Endocrinology, #DiabeticKetoacidosis, #DiabetesTreatment, #DiabetesResearch, #MetabolicDisorders, #GlucoseControl, #BetaCells, #AlphaCells, #PancreaticHealth #keto #metabolicclassroom #benbikman #drbenbikman Timestamps (approximate): 00:01 – Rethinking the Insulin-Centric Model 01:04 – Dr. Roger Unger and the Bi-Hormonal Hypothesis 03:15 – Glucagon: The Forgotten Hormone 05:17 – Glucagon Physiology and Liver Function 08:23 – Pericrine Regulation in Pancreatic Islets 10:36 – What Goes Wrong in Type 1 Diabetes 12:45 – Glucagon Secretion Without Insulin 13:50 – Glucagon’s Role in Ketogenesis and Protein Breakdown 15:54 – The Limits of Injected Insulin 17:58 – Why Systemic Insulin Misses the Mark 19:10 – Explaining Glucose Variability and High Insulin Needs 21:34 – Clinical Implications of Hyperglucagonemia 23:32 – Muscle Wasting and Amino Acid Shuttling 24:29 – Blocking Glucagon: A Therapeutic Strategy 25:29 – Type 2 Diabetes and Glucagon Resistance 26:21 – Drug Therapies Targeting Glucagon 28:31 – GLP-1 Drugs as Glucagon Suppressors 29:37 – Final Thoughts: A Paradigm Shift in Diabetes Treatment Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd
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In this episode, we will dive deep into how the keto diet may be killing your gut health by starvation! Yes, you read that right! I will provide my personal experience and a few actional tips to improve your gut health if you decide to stay on a keto diet or if are looking for a healthy long-term lifestyle! Make sure to comment below what your fiber goal is! Don't forget to share and subscribe!
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