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Master the pharmacology of diabetes treatments with this comprehensive medical lecture. Designed for medical students, pharmacy students, physicians, pharmacists, and nurses, this session covers the mechanisms of action, effects, side effects, and clinical considerations for major classes of anti-diabetic drugs, including sulfonylureas, metformin, TZDs, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors, and insulin. This in-depth lecture explores critical aspects of diabetes pharmacology, including: [00:14] Sulfonylureas (SUs): [02:26] Mechanism: Stimulating insulin secretion via ATP-sensitive K+ channel blockade. [04:31] Side Effects: Hypoglycemia, weight gain. [08:47] Meglitinides: Similar insulin secretagogue action, different binding site, [09:43] short-acting. [14:16] Metformin (Biguanides): Mechanism: Reducing hepatic glucose production. [22:56] Side Effects: GI disturbances, lactic acidosis risk. [25:25] Thiazolidinediones (TZDs / Glitazones): Mechanism: PPAR gamma agonists, increasing insulin sensitivity. [30:15] Side Effects: Weight gain, edema. Incretin-Based Therapies: [33:09] GLP-1 Physiology: Origin from preproglucagon. [37:04] DPP-4 Inhibitors: Mechanism (increase endogenous GLP-1 levels). [39:25] GLP-1 Receptor Agonists (GLP-1 RAs): Examples (Semaglutide, Liraglutide); [38:57] Side effects (nausea, vomiting). [47:59] SGLT2 Inhibitors: Mechanism: Increasing urinary glucose elimination. [52:26] Side Effects: UTIs, genital infections. [53:07] Alpha-glucosidase Inhibitors: Mechanism: Reducing carbohydrate absorption. [53:57] Side Effects: Flatulence, diarrhea. [54:41] Pramlintide (Amylin Analog): Mechanism (reduces gastric motility & glucagon secretion). [56:24] Bromocriptine: Dopamine receptor agonist used for glucose lowering. [57:26] Insulin: Role in Type 2 Diabetes management. Key Learning Objectives: Understand the mechanisms of action for major classes of anti-diabetic medications. Identify common and significant side effects associated with each drug class. Differentiate between various diabetes drug classes based on their primary targets and effects (e.g., insulin secretagogues, sensitizers, incretin-based, glucose excretion enhancers). Appreciate the pharmacological basis for choosing different therapies in diabetes management. SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PHARMACOLOGY by Dr. Neeladri Majumder (MBBS Batch: 2023-24) Conducted on: 03-04-25
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