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Weight loss medications like Ozempic, Semaglutide, Wegovy, Mounjaro, and Zepbound have been gaining popularity. They seem like the perfect answer for people with Hashimoto’s or hypothyroid and who are struggling to lose weight. Are they the right option for you? It can be hard to find factual answers because people have OPINIONS on this topic! This episode will help you make an informed decision on if one of these weight loss medications would be a good tool for you. I’d love to hear from you! Have you used Ozempic, Wegovy, or any of the other medications? Come over to our Skool community and join the conversation. https://www.skool.com/health-with-hashimotos/about MENTIONED ON THIS EPISODE: Healthy Weight Stack: https://estheryunkin.lifevantage.com/us-en/shop/healthy-weight-stack Coffee Episode: https://healthwithhashimotos.com/coffee-and-thyroid-meds/ (https://healthwithhashimotos.com/?p=2138&preview=true) JOIN THE COMMUNITY Unlock your wellness journey with the free Health with Hashimoto's community! Join a supportive community that's here for you every step of the way. Our community is now on Skool: https://www.skool.com/health-with-hashimotos/about YOUR PATH TO HEALTH WITH HASHIMOTO’S STEP 1 - Hashimoto's Decoded: 10 Thyroid Questions to Ask Your Doctor. https://healthwithhashimotos.com/questions-for-your-doctor/ STEP 2 - Hashimoto's Decoded: Root Causes Revealed. https://hwh.passion.io/checkout/157602 STEP 3: The Holistic Hashimoto’s Course https://healthwithhashimotos.com/holistic-hashimotos-course/ ABOUT THE PODCAST & ESTHER: The Health with Hashimoto’s podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto’s thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional.
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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]
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The Biden administration has proposed a plan to allow Medicare and Medicaid to cover obesity medications like Ozempic and Wegovy, which are currently only covered for patients with diabetes or heart disease. A University of Michigan poll shows strong support among older adults for this coverage, but cost remains a concern, as these drugs can exceed $1,300 per month. Dr. Lauren Oshman emphasizes their effectiveness in helping patients lose significant weight and reducing risks associated with chronic conditions, though the decision on coverage will ultimately be made by the Trump administration due to timing.
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Shark Tank is a popular television show where entrepreneurs pitch their business ideas to a panel of potential investors with hopes of securing funding to help bring their dreams to life. One recent partnership that has taken the health and wellness industry by storm is the collaboration between Shark Tank and Keto BHB supplements. This unique partnership has propelled Keto BHB into the spotlight and has helped countless individuals achieve their weight loss and wellness goals.
The Power of Shark Tank
Shark Tank has a proven track record of taking innovative products and ideas and turning them into successful businesses. With a panel of seasoned investors who have the knowledge and experience to assess the viability of a business, entrepreneurs who appear on Shark Tank have the opportunity to receive not only financial backing but also valuable guidance and mentorship. This platform has launched numerous successful products and companies, and the partnership with Keto BHB is just one example of the power of Shark Tank.
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When a product or idea is featured on Shark Tank, it gains instant credibility and exposure. The show has a large and dedicated following, and viewers trust the judgment of the investors on the panel. This instant validation can catapult a product into the mainstream and open up a world of opportunities for the entrepreneurs behind it. By partnering with Shark Tank, Keto BHB was able to leverage the show’s reach and credibility to reach a wider audience and gain the trust of consumers looking for effective weight loss solutions.
One of the key benefits of partnering with Shark Tank is the access to the panel of investors, who bring a wealth of knowledge and expertise to the table. These investors have years of experience in business and can provide valuable insights and guidance to help the entrepreneurs behind Keto BHB navigate the challenges of scaling their business. The mentorship and support provided by the Shark Tank investors can be instrumental in the success of a business, and the partnership with Keto BHB is a testament to the value of this mentorship.
The Keto BHB Phenomenon
Keto BHB supplements have gained popularity in recent years as a powerful tool for weight loss and overall wellness. These supplements are designed to help the body enter a state of ketosis, where it burns fat for energy instead of carbohydrates. By supporting the body’s natural ketone production, Keto BHB supplements can help individuals reach their weight loss goals and improve their energy levels and mental clarity.
One of the reasons Keto BHB supplements have become so popular is their effectiveness. Many people struggle to lose weight and keep it off, despite trying various diets and exercise routines. The ketogenic diet, which is high in healthy fats and low in carbohydrates, has been shown to be effective for weight loss, but it can be challenging to maintain. Keto BHB supplements provide a convenient and effective way to support ketosis and help individuals stay on track with their weight loss goals.
In addition to weight loss, Keto BHB supplements offer a range of benefits for overall health and wellness. By supporting ketosis, these supplements can help improve energy levels, mental clarity, and focus. They can also help regulate blood sugar levels and reduce cravings for unhealthy foods. Many people who take Keto BHB supplements report feeling more energetic, focused, and satisfied throughout the day, making it easier to stick to their weight loss goals and maintain a healthy lifestyle.
Final Thoughts
The partnership between Shark Tank and Keto BHB supplements has been a game-changer for both parties. By leveraging the reach and credibility of Shark Tank, Keto BHB was able to gain the exposure and validation needed to become a leading brand in the health and wellness industry. The support and mentorship provided by the Shark Tank investors have been instrumental in the success of Keto BHB, and the partnership has helped countless individuals achieve their weight loss and wellness goals. As the demand for effective weight loss solutions continues to grow, the collaboration between Shark Tank and Keto BHB serves as a shining example of how innovation, partnership, and determination can lead to success in the competitive world of business.
Overall, the Shark Tank and Keto BHB partnership has created a win-win situation for both sides. The exposure and credibility provided by Shark Tank have helped Keto BHB become a trusted and respected brand in the health and wellness industry, while the support and mentorship from the Shark Tank investors have helped the entrepreneurs behind Keto BHB navigate the challenges of scaling their business and reaching new heights of success. As the popularity of Keto BHB supplements continues to grow, the partnership with Shark Tank will undoubtedly play a key role in helping Keto BHB maintain its position as a leader in the weight loss and wellness market.
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Watch this video as Dr. Christina Beer, Product Formulator of Lifevantage, deep dive into our NEW MindBody GLP-1 System. MindBody GLP-1 System™ Turn down food noise, quiet cravings, and hush hunger with the next evolution in Activation–the MindBody GLP-1 System™. This patent-pending system is clinically shown to naturally increase GLP-1 by an average of 140%. Use it as part of an Activated lifestyle to take back control and build better habits to help you achieve your health goals. For best results, we recommend at least 3 months of consistent daily use. Results will vary.*Ω‡ Contents: MB Core™ 60 capsules, MB Enhance™ 30-day supply ------------------------------------------------------------------ Increase GLP-1 Naturally with Activation Science*Ω Activation works with your unique biology to gradually increase GLP-1, balance hunger hormones, and strengthen the mind-body connection. Over time, cravings and hunger decrease so you can reshape your relationship with food for a sustainable way to support wellness and weight loss goals. After 12 weeks, participants in a clinical study experienced significant improvements: *‡ • Increased GLP-1 by 140% on averageΩ • 82% took back control of their relationship with food* • 95% had decreased sugar cravings* • Lost up to 25 lbs. in 12 weeks (an average of 1–2 lbs. a week)‡ • 100% who lost weight did not lose muscle*‡ • Lost up to 27% in visceral fat‡ Whether you want to lose a few lbs. or simply make smarter food choices, the MindBody GLP-1 System is here to support you at every step. It’s not a quick fix. It’s a way to work with your body—not against it—to experience the benefits when of resetting your gut and rebalancing GLP-1 and hunger hormones to more optimal levels. Use it as part of an Activated Lifestyle with the right nutrition, movement, and mindfulness practices every day to become your strongest, healthiest self.*‡ Benefits Naturally Increases GLP-1 Ω Quiets “food noise” to cut down cravings and reduce the desire to snack* Supports sustainable weight loss and wellness for results you can see and feel. *‡ Helps balance hunger hormones to increase satiety via gut-brain axis, so you feel fuller, longer* Helps maintain blood sugar levels already within a normal healthy range* _________________________________________________ For more information visit my website https://www.naturehealth.com.au/ or email me at [email protected]. Tiktok: https://www.tiktok.com/@natural.weight.lo?lang=en Facebook: https://www.facebook.com/margie.hare.9/