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This is the big, super comprehensive Press-Pulse overview paper that Dr. Seyfried and collegues published in late 2024: A behemoth of a paper, with 30 pages of text and 750 references! " Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma " It is not only about glioblastoma, but also for all cancers! (That get their energy from glucose and glutamine.) We recommend strongly, that you do read the paper yourself (esp. as a professional), as this version is a shortened one, where the information that is important and useful for PATIENTS was highlighted. It is mostly targeted at researchers and doctors, but also directly at patients that want to learn more about this new method and how to go about it, also talking about DON administration and other Glutamine inhibitors. Thus, the paper is split into 2 parts, with part 2 also containing the figures and tables. Shorthand terms that were replaced: SOC standard of care mOS median overall survival KMT ketogenic metabolic therapy GBM glioblastoma SLP substrate-level phosphorylation KDs ketogenic diets β-HB β-hydroxybutyrate (=ketones) LBM lean body mass (=muscle mass) KD-R calorie restricted ketogenic diet CGM continuous glucose monitoring CKM continuous ketone monitoring FMDs fasting-mimicking diets IRB Institutional Review Board (the ones approving, financing the studies) Also for better understanding, "SLP" or "SLP flux" was replaced with "fermentation" Source: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03775-4 Produced by & for https://skool.com/Ketoforcancer , where we help you implement the press pulse strategies in real, everyday life! Check it out :-) We also have a great deal of analysis of this paper in a summary format, as well as the most important studies in PDF format, ready to be downloaded.
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Mounjaro diary - day 8 of my 2nd week on the weight loss medication. I’ve decided to stretch the week out and go an extra day and a half. Possible side effect - losing my eyelashes.
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Click Here to Subscribe: http://Bit.ly/ThomasVid Get Grass-Finished Meat Delivered to Your Doorstep with Butcher Box: https://butcherbox.pxf.io/c/1434763/1577973/16419 Website: http://ThomasDeLauer.com The 4 Week Keto Diet - How to Cut on Keto - Thomas DeLauer Resistance Training Meta Analysis - Nutrients Looked to see if resistance training prevents muscle loss induced by caloric restriction The review randomized clinical trials (RCT) comparing the effects of CR with (CRRT) or without RT on lean body mass (LBM), fat body mass (FBM), and total body mass (BM) The six RCTs included in the review applied RT three times per week, for 12 to 24 weeks, and most CR interventions followed diets of 55% carbohydrate, 15% protein, and 30% fat RT reduced 93.5% of CR-induced LBM loss (0.819 kg [0.364 to 1.273]), with similar reduction in FBM and BM, compared with CR Concluded that CRRT is able to prevent almost 100% of CR-induced muscle loss, while resulting in FBM and BM reductions that do not significantly differ from CR. Despite losing weight, resistance training still tears the actin and myosin, forcing the body to repair them, building them back up https://www.ncbi.nlm.nih.gov/pubmed/29596307 Fasted Training Fasting & Hormone Sensitive Lipase Exercising in a fasted state increases both lipolysis and fat oxidation rates - Your body's fat burning processes are controlled by your sympathetic nervous system and your SNS is activated by exercise and lack of food When you train with your insulin at a baseline level, your body is able to both mobilize and burn more fat during your workouts than when insulin levels are elevated The combination of fasting and exercising maximizes the impact of cellular factors and catalysts (cyclic AMP and AMP Kinases), which force the breakdown of fat and glycogen for energy Study - The Journal of Physiology: Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464435/ Study from the European Journal of Applied Physiology Subjects were split into two groups that were trained on two occasions separated by three weeks - one of the sessions was performed on an empty stomach after an overnight fast Found: Increased p70s6k phosphorylation during intake of a protein–carb drink following resistance exercise in the fasted state - fasted training group saw a bigger increase in p70s6k p70s6 kinase serves as an indicator of muscle growth https://link.springer.com/article/10.1007%2Fs00421-009-1289-x Supplements DIM DIM is a naturally occurring byproduct of indole-3-carbinol (IC3), and IC3 helps the liver to metabolize estrogen more efficiently via upregulating the CYP1A2 enzyme (CYP1A2 is an enzyme that helps to break down toxins in our bodies) It also simultaneously converts strong estrogen molecules into less potent ones (via downregulation of the CYPB1B enzyme and upregulation of CYP1A2 enzyme) - results in reduced estrogen levels and a more favorable estradiol/estrone ratio Fish Oil (Muscle Growth & Fat Loss) Muscle Growth A study published in the journal Clinical Science looked at 9 healthy participants, age 25-45, who led a sedentary lifestyle that supplemented with 4 grams of DHA and EPA daily for an 8-week period The pathways which regulate protein synthesis (mTORSer2448 and p70s6kThr389) increased by roughly 50% (50% more active in the presence of higher omega-3 fatty acid levels) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499967/ Fat Loss Study 1 - Satiation A study published in the journal Appetite looked at the effects of omega 3’s on appetite- was assessed in humans taking part in calorie restricted weight loss diets. Participants were given 1 of 4 diets including no seafood, lean fish 3 times a week, fatty fish 3 times a week and omega 3 capsules (6 a day) Scientists found that those who consumed meals high in omega 3’s felt more full directly after and 2 hours after Omega 3’s modulated hunger signals that control hunger and fullness in the body, which can help you eat less and lose weight - specifically modulated postprandial satiety https://www.ncbi.nlm.nih.gov/pubmed/18602429 Study 2 - Brown Fat & White Fat A Japanese study published in Scientific Reports fed two groups of mice a high-fat diet - one group, however, also consumed fish oil The latter group gained significantly less weight and fat, and had a hotter core temperature, due to an increase in brown fat https://www.nature.com/articles/srep18013 Magnesium Magnesium directly interacts with your muscle tissue through a process called ion transportation It bonds with specific receptor sites that open up the cell membrane and allow other mineral ions to enter, such as calcium and potassium - these ions help regulate muscle contractions and might ease muscle tension
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