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Weight loss drugs have become an increasingly popular, but controversial, way of quickly shedding extra pounds over the past few years. Part of that controversy deals with the side effects caused by some of the more well-known medications like Ozempic and Mounjaro. According to the Obesity Medicine Association (OMA), researchers are continually analyzing the pros and cons of these drugs. Here are some side effects of the eight FDA-approved weight loss drugs: Ozempic and Wegovy Ozempic and Wegovy are the brand names of a drug known as semaglutide, a medication that, according to Harvard Health, has been prescribed for about two decades to treat Type 2 diabetes. Ozempic has become controversial over the past few years as overweight and obese patients have sought it out for weight loss, creating a shortage of the drug for those using it to control their diabetes. Wegovy is the brand name for a form of semaglutide that has since been approved for weight loss. Semaglutide, which mimics a natural hormone called GLP-1, helps regulate blood sugar while slowing down the emptying of the stomach and signaling satiety or fullness to the brain. The OMA reports that the most common complaint among patients using semaglutide is gastrointestinal issues like nausea. Other side effects include fatigue, dizziness, headache, bloating, belching and heartburn.An American Medical Association study has also found that GLP-1 agonists are associated with an increased risk of pancreatitis, bowel obstruction, and gastroparesis. While headlines have warned about an increase in suicidal ideation with semaglutide, a January 2024 study in Nature Medicine suggested “a 49% to 73% lower risk of first-time or recurring suicidal ideations” compared with other obesity medications. Mounjaro and Zepbound Mounjaro and Zepbound are drugs known as tirzepatide. Mounjaro was approved in 2017 to treat Type 2 diabetes, while Zepbound was approved in more recent years to treat obesity. Like semaglutide, tirzepatide is a GLP-1 agonist that increases a person’s feeling of fullness and helps them maintain a weight loss diet. It causes common mild symptoms like nausea, constipation, diarrhea and bloating, but the OMA reports more serious side effects like kidney problems up to and including kidney failure, gallbladder symptoms, pancreatitis and hypoglycemia. Manufacturer Eli Lilly warns, however, that Tirzepatide may cause thyroid tumors or thyroid cancer. Patients should monitor themselves for symptoms like neck swelling, hoarseness, problems swallowing and shortness of breath. Contrave Contrave is the brand name for a medication that combines two drugs, bupropion and naltrexone. Bupropion, which is marketed under the brand name Wellbutrin, is an antidepressant that is also known to reduce a person’s appetite. Naltrexone, commonly sold under the brand names Revia and Vivitrol, is a medication used to treat drug and alcohol addiction. According to Drugs.com, naltrexone works by blocking the euphoric, intoxicated feeling of alcohol and opioids. It also helps reduce the cravings for the substances. The OMA reports that patients should not be prescribed Contrave if they suffer from a seizure disorder or if they take opioids for chronic pain. The most common side effects of the drug are nausea, vomiting, constipation, diarrhea, headache, dizziness, dry mouth and insomnia. Saxenda Saxenda is a medication containing liraglutide, a drug that mimics a person’s natural hormones affecting hunger, digestion and feelings of fullness. It was approved by the FDA in 2017 to treat obesity in people 12 and older. The most common side effects of liraglutide are nausea, vomiting, constipation, diarrhea, headache, fatigue, dyspepsia, dizziness and abdominal pain. It can also cause increased heart rate, increased lipase, which is a pancreatic enzyme, and decreased kidney function. Qsymia Qsymia is a medication that combines the drugs phentermine and topiramate. According to the OMA, phentermine has been around since 1959, making it the oldest and most widely used weight loss medication. The drug, which works in the brain as an appetite suppressant, is a stimulant similar to amphetamines and can be abused. It should not be used by patients who have suffered a stroke or who have heart disease, glaucoma or hyperthyroidism. The side effects of phentermine can be serious, including fast or irregular heart rate, headache, overstimulation, high blood pressure and tremors. It can also interact with several other drugs, including MAO inhibitors, alcohol, adrenergic neuron blockers and some anesthetic agents. When phentermine is combined with topiramate, an anticonvulsant, its effect on hunger is magnified. The side effects of the two drugs combined include dizziness, abnormal sensations, altered taste, insomnia, constipation and dry mouth. Topiramate also carries a risk of birth defects, so it should not be taken during pregnancy.
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******** July 28 2009 ****** I found something even better than fasting to lose weight. Check out my video Getting Younger III Just by drinking the water I have lost 10 pounds with out even paying attention or fasting ********Using yoga and science discover the ancient method of rejuvenation. Learn how to cure type II diabetes in less than a year Feb.7 - 262 lbs. Feb. 28 - 255 lbs Check back later for other weights. march 4 -253 march 11 -253 march 21 - 257 oops weight went up. I have started eating whatever I want now, just to see how I feel. I feel wonderful, even though I started eating things like pizza again( almost a whole pie at one sitting). The taste of food is much better, even during the whole week - not just after the fast is broken. I had three bagels with cream cheese and butter this morning. Delicious. It is comforting to know that even though I eat whatever I want, whenever I want when I an not fasting, the weight does not balloon like it did when I did other diets. If I want, I could fast a second day during the week and the weight will go down. April 29, 2008 Weight was 254.5 after fast on Monday. I am now fasting two days during the week for last 2 weeks. Weight has come down, but slowly. I am still eating very high caloric food, such as whipped cream, birthday cake, etc. It is some kind of karmic thing, I guess. But my waistline continues to contract. I had to drill some holes in my belts, as they no longer held up my pants. Two other facts stand out.My stomach has shrunk considerably. I cannot eat two baked potatoes at a sitting, as I could before. I was extremely full after 1. So I guess this is the cheap alternative to stomach stapling. The second thing I noticed was my skin texture changed to a much smoother feel. I did not notice this effect with the weekly fast. I do know that the skin does get rid of toxins through the skin. Perhaps this effect is due to the continued fasting rather than the 2 days per week. May 25, 2008. - I am still at the same weigth, in spite of fasting two days a week. I have noticed that I am finally now decreasing the total amount of food I am now eating, so I know the calorie count is now going down. I am going to now start a Hatha Yoga regimen, to enhance the further loss of weight. I do feel much better, even if I still have the same weight. My blood pressure seems to have normalized at 120/80. I have come across a wonderful free book on fasting, which covers some of the points made, plus a great deal more. The link is; http://quickfasting.com/index.html Nathaniel Bronner Jr. has taken a scientific look at fasting. I highly recommend it.
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