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#diabetes #weightloss #antihungermedicine Weight loss by diabetes drug linked to "anti-hunger" molecule, finds study Researchers from Stanford Medicine and Harvard Medical School have discovered an “anti-hunger” molecule that is produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The finding published in the journal Nature Metabolism revealed the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite which may help to discover a new class of weight loss drugs. Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug. Although this amount of weight loss is modest when compared with the 15% or more often seen by people taking semaglutide drugs, the discoveries that led to those drugs also grew from observations of relatively minor, but reproducible, weight loss in people taking first-generation versions of the medications. “Until now, the way metformin, which is prescribed to control blood sugar levels, also brings about weight loss has been unclear,” said Jonathan Long, PhD, an assistant professor of pathology. “Now we know that it is acting through the same pathway as vigorous exercise to reduce hunger. Understanding how these pathways are controlled may lead to viable strategies to lower body mass and improve health in millions of people.” The researchers observed obese laboratory mice who were given metformin and found increased levels of lac-phe in their blood. They ate less than their peers and lost about 2 grams of body weight during the nine-day experiment. In the study, Long and colleagues analyzed blood plasma samples from people with Type 2 diabetes before and 12 weeks after starting metformin treatment. They found significant increases in lac-phe levels post-metformin. Additionally, among 79 participants in a multi-ethnic atherosclerosis study taking metformin, those on the drug had higher circulating lac-phe levels compared to non-users. Moreover, a statistical analysis of individuals in the atherosclerosis study who experienced weight loss over the study and follow-up period revealed a significant connection between metformin usage, lac-phe production, and weight reduction. “It was nice to confirm our hunch experimentally. The magnitude of effect of metformin on lac-phe production in mice was as great as or greater than what we previously observed with exercise. If you give a mouse metformin at levels comparable to what we prescribe for humans, their lac-phe levels go through the roof and stay high for many hours.” said Long. “These findings suggest there may be a way to optimize oral medications to affect these hunger and energy balance pathways to control body weight, cholesterol and blood pressure. I think what we’re seeing now is just the beginning of new types of weight loss drugs.” Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/
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What good milk replacement have you tried on the keto diet? We've explored different types of milk replacement you can use on keto. #TarasKetoKitchen #WholeBodyLiving 💬 COMMENT below: What's your favorite milk replacement you use for keto diet? Have you tried other milk replacements? Share them below. 🛒 List: Unsweetened Coconut Milk: https://www.wholebodyliving.com/cq87 Full Fat Unsweetened Coconut Milk: https://www.wholebodyliving.com/i0tq Unsweetened Almond Milk: https://www.wholebodyliving.com/rpr6 Unsweetened Macadamia Nut Milk: https://www.wholebodyliving.com/krmg ⏲ TIMESTAMPS: 00:00 - What Is A Good Replacement For MILK On The Keto Diet? 00:42 - Cream & Water 01:20 - Other options Next... Join us live each Sunday evening to start your week off right! Subscribe and set that little bell icon to NOTIFY :-) Hey! It's Health Coach Tara! Creator of Tara's Keto Kitchen & Whole Keto. I want to take a moment to personally thank YOU for being here (and for reading this!). Your support is so appreciated! I've created a support group where you can connect with me & Jeremy and other people living a keto lifestyle just like you! You can check it out with the link below: https://www.wholebodyliving.com/freeketogroup Learn about membership at https://www.wholebodyliving.com/membership Disclaimers: We are affiliates for many products we love & use...Why affiliate links? They help support my Vlog :-) Thank you for considering using my affiliate links. How do they work? When you click on them and make a purchase, my blog gets a small % as a kickback for referring you based off the total dollar amount in your cart. This costs you nothing extra and is a free (to you) way to help support my blog & help me afford to continue to be able to experiment and develop recipes. Thank you so much for considering using my Amazon (and other) affiliate links. Thank you for helping to make these keto recipes possible and free! Want more? Leave your comments below with your keto recipe requests! Visit my website at www.wholebodyliving.com to find out more about me and what I’ve been up to lately. Pinterest: https://www.pinterest.com/tarasketokitchen/ Twitter: https://twitter.com/TaraKetoKitchen Facebook: https://www.facebook.com/TarasKetoKitchen Instagram: https://www.instagram.com/tarasketokitchen/ Website: https://www.WholeBodyLiving.com Youtube: https://www.youtube.com/tarasketokitchen Tara Wright, Whole Body Living, LLC and Tara's Keto Kitchen provide information on this YouTube Channel and associated website regarding healthy living, recipes, nutrition, and diet which are intended for informational purposes only. The information provided is not a substitute for medical advice, diagnosis, or treatment nor is it to be construed as such. Although every effort is made, information and research can change rapidly. We cannot guarantee that the information provided reflects the most up-to-date medical research. Information is provided without any representations or warranties of any kind. Please consult a qualified physician for medical advice, and always seek the advice of a qualified healthcare provider before making any changes to your nutrition or exercise program. Young Living Independent Distributor #1433705 As a Young Living Independent Distributor I earn from qualifying purchases. Note: As an Amazon Associate I earn from qualifying purchases. Thank you so much for choosing to purchase through me!
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