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Subscribe: https://youtube.com/@drtyna This one shook me. A brand new 2024 study in Advanced Science shows that botulinum toxin, the active ingredient in Botox, Dysport, and Xeomin, can travel to the brain, trigger inflammation, damage synapses, and create changes that closely resemble early Alzheimer's. In this episode, I break down what the researchers found, how it connects to microglial activation, chronic pain, memory, and hormone shifts. ___________________________________________________________________________ Social & Website: Instagram - https://www.instagram.com/drtyna/ Website - https://www.drtyna.com/ Store - https://store.drtyna.com/ Courses - https://www.drtyna.com/store Metabolic Revamp Toolkit: https://bit.ly/drtynametabolicrevamp FREE GUIDE: Assess Your Metabolic Health: https://www.drtyna.com/metabolism GLP-1’s Uncovered FREE 4 Part Video Series https://www.drtyna.com/offers/VstUywXc/checkout Subscribe to The Dr. Tyna Show: Apple Podcasts: https://apple.co/4bm3R3m Spotify: https://spoti.fi/3OtOps7 Substack: https://drtyna.substack.com/ ___________________________________________________________________________ Topics Discussed: → Can Botox travel to your brain? → Does Botox increase your risk of Alzheimer’s? → What does Botox do to brain cells? → Is microglial activation linked to Botox use? → Are neuromodulators like Dysport and Xeomin safe long-term? On This Episode We Cover: → 00:00:00 - Introduction → 00:05:23 - The brain & your immune system → 00:07:24 - The microglial system → 00:09:29 - Study breakdown and findings → 00:14:25 - Different forms of botox & side effects ___________________________________________________________________________ Show Links: → Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses Further Listening: → EP. 185 | 10 Health Trends We Are Ditching in 2025 | Solo ___________________________________________________________________________ Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. #drtynashow #podcast #drtyna #thedrtynashow #quickanddirty
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In episode 1125 of Mark Bell’s Power Project Podcast, hosts Mark Bell, Nsima Inyang, and Andrew Zaragoza hang out with guest Brad Kearns to uncover the ultimate fat-burning running tips. Learn why sprinting beats jogging, the benefits of walking for endurance, and how to avoid injuries while improving your fitness. Brad shares insights on proper running form, heart rate training, recovery, and the truth about modern running shoes. If you're ready to train smarter, build strength, and burn fat, this episode is for you. Tune in now! Follow Brad on IG: https://www.instagram.com/bradkearns1/ Official Power Project Website: https://powerproject.live Join The Power Project Discord: https://discord.gg/yYzthQX5qN Subscribe to the Power Project Clips Channel: https://youtube.com/channel/UC5Df31rlDXm0EJAcKsq1SUw Special perks for our listeners below! 🥜 Protect Your Nuts With Organic Underwear 🥜 ➢https://nadsunder.com/ Use code: POWERPROJECT to save 15% off your order! 🍆 Natural Sexual Performance Booster 🍆 ➢https://usejoymode.com/discount/POWERPROJECT Use code: POWERPROJECT to save 20% off your order! 🚨 The Best Red Light Therapy Devices and Blue Blocking Glasses On The Market! 😎 ➢https://emr-tek.com/ Use code: POWERPROJECT to save 20% off your order! 👟 BEST LOOKING AND FUNCTIONING BAREFOOT SHOES 🦶 ➢https://vivobarefoot.com/powerproject 🥩 HIGH QUALITY PROTEIN! 🍖 ➢ https://goodlifeproteins.com/ Code POWER to save 20% off site wide, or code POWERPROJECT to save an additional 5% off your Build a Box Subscription! 🩸 Get your BLOODWORK Done! 🩸 ➢ https://marekhealth.com/PowerProject to receive 10% off our Panel, Check Up Panel or any custom panel, and use code POWERPROJECT for 10% off any lab! Sleep Better and TAPE YOUR MOUTH (Comfortable Mouth Tape) 🤐 ➢ https://hostagetape.com/powerproject to receive a year supply of Hostage Tape and Nose Strips for less than $1 a night! 🥶 The Best Cold Plunge Money Can Buy 🥶 ➢ https://thecoldplunge.com/ Code POWERPROJECT to save $150!! Self Explanatory 🍆 ➢ Enlarging Pumps (This really works): https://bit.ly/powerproject1 Pumps explained: ➢ https://withinyoubrand.com/ Code POWERPROJECT to save 15% off supplements! ➢ https://markbellslingshot.com/ Code POWERPROJECT to save 15% off all gear and apparel! Follow Mark Bell's Power Project Podcast ➢ https://www.PowerProject.live ➢ https://lnk.to/PowerProjectPodcast ➢ Insta: https://www.instagram.com/markbellspowerproject ➢ YouTube: https://www.youtube.com/markbellspowerproject FOLLOW Mark Bell ➢ Instagram: https://www.instagram.com/marksmellybell ➢https://www.tiktok.com/@marksmellybell ➢ Facebook: https://www.facebook.com/MarkBellSuperTraining ➢ Twitter: https://twitter.com/marksmellybell Follow Nsima Inyang ➢ Become a Stronger Human - https://thestrongerhuman.store ➢ UNTAPPED Program - https://shor.by/JoinUNTAPPED ➢YouTube: https://www.youtube.com/c/NsimaInyang ➢Instagram: https://www.instagram.com/nsimainyang/?hl=en ➢TikTok: https://www.tiktok.com/@nsimayinyang?lang=en Follow Andrew Zaragoza ➢ Podcast Courses and Free Guides: https://pursuepodcasting.com/iamandrewz ➢ Instagram: https://www.instagram.com/iamandrewz/ ➢ TikTok: https://www.tiktok.com/@iamandrewz Chapters: 0:00 Introduction: Fitness Secrets Revealed 0:04 Jumping for Fat Loss 5:52 Safe Jump Training with Rebounders 7:38 Smarter Jump Training Tips 11:38 Explosive Performance Mindset 13:31 Willpower of Champions 18:43 Balancing Intensity and Awareness 23:33 Risks of Masking Pain 28:45 Longevity for Aging Athletes 32:05 Recovery Hacks for Success 33:48 Build Skill Before Intensity 37:06 Aerobic Workouts for Tough Training 38:58 Sprint Like the Pros 42:32 Sprinting Speed Secrets 47:56 Long Runs and Hidden Dangers 49:41 When Pushing Too Hard Backfires 53:11 Zone 1: The Aerobic Sweet Spot 54:54 Walking Over Jogging Benefits 58:18 Endurance Overeating Trap 1:03:49 Overtraining Warning 1:05:35 Super Shoes: Help or Hype? 1:09:09 How Running Shoes Changed 1:11:00 Modern Shoes Ruining Form? 1:14:30 Stay Off Concrete! 1:19:50 Perfect Running Form Tips 1:25:08 Fat Max Heart Rate Explained 1:27:01 Balancing Duration & Intensity 1:30:34 Is Running an Addiction? 1:32:21 When Running Obsession Hurts 1:35:54 The Truth About Marathons 1:37:51 Are Extreme Runs Worth It? 1:41:33 How Female Runners Dominate 1:43:22 Meet Noah Lyles: The Fastest Man 1:46:55 Energy Systems Explained 1:48:44 Aerobic vs Anaerobic Secrets 1:52:21 Balancing Strength & Endurance #PowerProject #Podcast #MarkBell #FitnessPodcast #markbellspowerproject
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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt
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Prescription weight loss pills, approved by healthcare professionals and agencies like the FDA, offer a medically supervised solution for obesity and related health issues when diet and exercise fall short. Medications like Orlistat, Phentermine-topiramate, and Semaglutide target appetite, fat absorption, or metabolism, aiding weight loss and reducing risks like diabetes and heart disease. While side effects and careful monitoring are necessary, these pills play a key role in comprehensive weight management when combined with lifestyle changes. Explore their potential in a holistic approach to better health.
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