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Delta 8 THC Compared to Delta 9 THC Professor DeBacco Delta-9 THC Explained As an activator of the CB1 receptor, delta-9-tetrahydrocannabinol — commonly known as THC is the main intoxicating component of cannabis. THC intoxication has been shown to increase blood flow to the prefrontal cortex, the region of the brain responsible for decision-making, attention, motor skills, and other executive functions. When THC binds to CB1 receptors in the brain's reward system, it can trigger feelings of euphoria. Much of THC's ability to relieve pain is due to its interaction with CB1 receptors in the midbrain. Delta-8 THC Explained Delta-8-THC is an isomer of Delta-9 THC It only differs from delta-9-THC by the placement of one atomic double bond. Generally, this chemical is produced in a lab, not extracted directly from the plant. It is actually synthesized from CBD Isolate. This creates a legal loophole, because the product is being sold as “hemp derived” even though it is actually a chemically produced THC isomer. Extraction Difference Delta 9 THC is a major cannabinoid that can be found in abundance and is easily extracted from in cannabis. Extracting Delta 8 THC is more challenging because it is a minor cannabinoid Synthesizing Delta 8 from CBD Delta 8 can be synthesized entirely from CBD with the use of solvents. Deriving Delta 8 from hemp ensures the final product is under the 0.3% THC level to be federally legal. Steps to Synthesize D8 THC from CBD isolate Dissolve into non-polar solvent of choice. Common solvents include heptane. Add a Lewis acid, like alumina, p-toluenesulfonic, or hydrochloric. Maintain the mixture at a temperature of 100 degrees C while continually stirring for upwards of 18 hours. Once the chemical reaction is complete, and the upper phase is separated, wash and neutralize the solution with 5% NaHCO3 Test for purity and contaminants using HPLC, separate the converted mixture into its “many cannabinoid parts”. Conversion is never 100% Different Effects Delta 9 is considerably more potent effects than Delta 8. Ex. paranoid delusions, mental fog, impaired motor skills, and increased feelings of anxiety. Delta 8 is reported to provide a more muted experience with most users feel a great sense of calm and clarity. However, many have reported a definite “high” to the experience, but not enough to impair the ability to form coherent thoughts or focus on activities. Onset Time Difference Delta 9 has an onset that is more rapid and instantaneous Delta 8 works slowly and gradually as it eases users into a more mellow state Similar End Products Both can be smoked as a flower, inhaled through vaping, consumed in edible form also with a wide variety of topicals, capsules, tinctures, edibles and other products. Legality Delta 9 THC in any amount over 0.3% is not legal at a federal level. State level depends entirely on their local laws. Delta 8 is still technically legal on a federal level. That's because of the ambiguities of the 2018 Farm Bill, which legalized hemp production. There is nothing within the bill that prohibits deriving Delta 8 from hemp and creating products with the compound. Hazy Area The psychoactive nature of Delta 8 has prompted a fair number of bans at the state level, though. Currently there are 15 states that restrict the sale and use of Delta 8 products, with another 6 states where legal action is pending. So while Delta 8 is more widespread at the moment than Delta 9, how long that will last has yet to be determined. Availability Delta 8 since it is federally legal can be shipped across state lines, unlike Delta 9. There are a lot more online retailers for Delta 8 products as a result. Remember: Delta 8 products are not regulated by the FDA, so it is up to you to seek out lab results tested from a third party lab. Delta 9 vs Delta 8 Delta 9 might be considered the “classic” choice by some within the cannabis community, Delta 8 has been quickly gaining in popularity due to its milder effects and legal availability. Since this is an isomer of Delta 9 it is also likely to come under some form of regulation in the future even though that may not currently be the case. Link to Lecture Slides: https://drive.google.com/file/d/1bTA2zy0R_dAN7zVTCzp0_XImiOmyHGlx/view?usp=sharing *Due to the description character limit the full work cited for "Delta 8 THC Compared to Delta 9 THC" can be viewed at... https://drive.google.com/file/d/1ET_IIIsXWyUZ_FuID5oXLumMOchlYSzr/view?usp=sharing
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CINCINNATI (WKRC) - Food products with CBD oil are being pulled from the shelves in Cincinnati. The Ohio Department of Agriculture is cracking down as medical marijuana stores are opening across the state. State officials now say only dispensaries can sell CBD products, but some store owners say CBD and marijuana are not the same. Two stores at Cincinnati’s Findlay Market were forced to remove CBD products from their shelves after they received visits from the Cincinnati Health Department. “This entire shelf was full of CBD seltzers and all the wonderful flavors,” said Debbie Gannaway who owns Gramma Debbie’s Kitchen. Gannaway says the CBD seltzers helped her arthritis. “People asking me, 'Well, is it really any good? Does it really do anything?' So, I decided I was going to do it every day so I could see, and the arthritis in my knee stopped bothering me,” said Gannaway. It’s the same story at Dean’s Mediterranean Imports. Owner Kate Zaidan says her customers enjoyed the products. “It was a great product for us. People loved it. We had repeat business," said Zaidan. “People would come back and tell us they had great effects from it.” CBD oil is a cannabis compound, but it does not contain THC. That’s the psychoactive compound found in marijuana that gives you a euphoric feeling. The Ohio Board of Pharmacy says the state’s new medical marijuana program only allows dispensaries to sell CBD products. “Well, I think it’s ridiculous. They need to figure out how to reword the law that hemp and hemp products are perfectly legal and should be used in any way possible,” said Gannaway. The Cincinnati Health Department says it's just following directions from the state. In a statement, Antonio Young, director of environment health at Cincinnati’s health department, said the department is just acting as an extension of the Ohio Department of Agriculture. Young said the issue will ultimately need to be handled by regulators like the Ohio Board of Pharmacy. “I just think it's a shame that access has been limited. To me, it's important that people have access to things that make their lives better,” said Zaidan. The CBD products pulled from the shelves have been embargoed. The store owners say the health department will pay them another visit in the coming days to determine if the products need to be destroyed. The Cincinnati Health Department released the following statement of Local 12: The Ohio Department of Agriculture (ODA) has identified retail food facilities throughout the state that may potentially be selling food containing Cannabidiol (CBD) products. CBD oil is derived from the cannabis plant, has become the new product in states that have legalized medical marijuana. Food and beverage products containing CBD were introduced in the United States in 2017. Similar to energy drinks and protein bars which may contain vitamin or herbal additives, food and beverage items can be infused with CBD as an alternative means of ingesting the substance. These products may only be legally sold by a licensed dispenser. On 1/31/2019, the Cincinnati Health Department’s Food Inspection office received a phone call from ODA stating that establishments within our health Jurisdiction may be affected. Local health departments were instructed by ODA to visit the City of Cincinnati locations and embargo the products. Embargoing involves identifying potentially harmful food products, having the products removed from retail sale; itemized/ inventoried and photographed on-site. The Cincinnati Health Department inspected all of the identified establishments. Only one establishment required an embargo. The remaining locations had either already removed the product from the shelves or altogether discontinued products for retail sale prior to the inspector’s visit. It is important to note that due to our jurisdictional authority and familiarly of these facilities, local health departments are acting as an extension of the ODA only. The issue will ultimately need to be handled at the distribution points by medical marijuana regulating entities such as the Ohio Board of Pharmacy."
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