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In 2018, the FDA granted approval to cannabidiol (CBD; Epidiolex) for the treatment of rare forms of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome, and while the addition was a welcomed one, this did not mark the complete understanding of the therapy’s use. Although CBD and other medications continue to be studied in some instances post-approval and often for other conditions, the need for subgroup analyses—especially in epilepsy—is paramount. As Kelly Knupp, MD, pediatric neurologist and epilepsy specialist, Children’s Hospital Colorado, pointed out in a conversation with NeurologyLive, when it comes to CBD, physicians still do not completely understand why specific subgroups of patients respond to CBD and others do not. “I think it would be worthwhile to look at that and try to figure that out,” Knupp said. The data from the clinical trials are compelling, she noted, but it’s important to remember that patients, while achieving reductions, have not been achieving seizure freedom. At the 2019 International Epilepsy Congress, June 22-26, in Bangkok, Thailand, she spoke about the use of cannabinoids in epilepsy and where they may play a role in other epilepsies.

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(4 Sep 2024) FOR CLEAN VERSION SEE STORY NUMBER: 4516054 ASSOCIATED PRESS Houston – 3 September 2024 1. Mid of products advertised as containing synthetically derived delta-8 THC are offered for sale at a smoke shop 2. Right-to-left pan of products displayed 3. Close-up on products displayed ASSOCIATED PRESS San Diego – 3 September 2024 ++PARTIALLY COVERED BY SHOT 1-3++ 4. SOUNDBITE (English) Igor Grant, Professor of Psychiatry UC San Diego: "The general concerns are in two areas. One is what does the chemical itself, the pure chemical let's say delta eight THC do. And the other is how is it manufactured and sold and whether there could be products within those products that themselves could be harmful." ASSOCIATED PRESS Houston – 3 September 2024 5. Top-to-bottom tilt shots of products advertised as containing synthetically derived delta-9 THC and CBD are offered for sale at a smoke shop. 6. Mid of products advertised as containing synthetically derived delta-8 THC 7. Wide of products advertised as containing synthetically derived delta-8 THC ASSOCIATED PRESS San Diego – 3 September 2024 ++COVERED BY SHOT 5-7++ 8. SOUNDBITE (English) Igor Grant, Professor of Psychiatry UC San Diego: "All of these processes introduce the possibility of some of these things that have been used to process the stuff lingering behind or contaminating the products." 9. SOUNDBITE (English) Igor Grant, Professor of Psychiatry UC San Diego: ++COVERED BY SHOT 10-12++ "So, buyer beware. And again, it's not so much. I think often the focus is on the delta 8. What does the delta-8 do to people? And, of course, we should be concerned about that. But I think it's more the case in the unregulated market. What else is in there that we don't know about?" ASSOCIATED PRESS Houston – 3 September 2024 10. Left-to-right pan of products on display 11. Closeup of products displayed 12. Mid of products advertised as containing synthetically derived delta-8 THC STORYLINE: They're sold in gas stations, vape shops, online and in other stores around the country in seemingly countless enticing forms: gummies, chocolate bars, chips. Their packaging lists things like delta-8 THC, micro- and macrodoses of “psychedelics” and “nootropics." These substances are often sold through legal loopholes, despite concerns about potential health risks and a lack of oversight of how they're produced. And in the absence of federal rules, many states have banned or have tried to ban delta-8 THC. Legal but under-regulated drugs are easy to come by, but experts say there are still a lot of uncertainties. Here's what to know. How are these substances legal? Drug laws are often specific to the substance, so federal and state regulators are left chasing the newest chemical concoction. Delta-8 THC exploded in popularity under the Agriculture Improvement Act of 2018, more commonly known as the Farm Bill. Under that law, hemp products and the cannabinoids that could be made from them were classified as distinct from marijuana. Delta-8 has just a slight chemical tweak from the psychoactive delta-9 compound found in marijuana, but it can still get you high. It remains in a legally ambiguous area with restrictions that vary state by state, said Robert Mikos, a marijuana policy and law expert at Vanderbilt University. Substances like cannabinoids are also easy to change into new but similar versions of drugs that may come under scrutiny. If it's on a store shelf though, it's safe, right? Not necessarily. He pointed to how delta-8 is made from CBD. What should you do? Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives ​​ Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/c3e334605eeb4147b3e86cc681f0731d

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