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Dr. Mark Scialdone is a recognized expert in the field of organic chemistry, specializing in natural product chemistry, including plant oil extraction, analysis, and chemical modification. He is an inventor of 37 issued US patents and has authored 17 peer-reviewed publications, during more than two decades of fundamental and product development research. He has given numerous invited lectures at more than 40 different academic institutions and international symposia. At CannMed 25, Mark participated in the Hemp-Derived Cannabinoids panel, which explored the rapid rise of products containing chemically transformed cannabinoids to exploit the 2018 Farm Bill loophole. He also presented a poster that explained the process for chemically converting cannabinoids in more detail. During our conversation we discussed: * Why producers and manufacturers would want to convert one cannabinoid into another * Common methods for cannabinoid conversion * Safety risks associated with chemical cannabinoid conversion * The legality of these compounds * How these compouns and these products are affecting the legal cannabis market * The therapeutic potential of novel, chemically-converted cannabinoids * and more Thanks to This Episode’s Sponsor: Cannabis & Tech Today Cannabis & Tech Today is the premier publication for the business, science, and innovations shaping the cannabis industry. From exclusive interviews with industry leaders to deep dives on the latest tech, they cover it all. Go to cannatechtoday.com to subscribe to their digital and print editions and gain access to exclusive interviews, brand-new technology, and thought-provoking articles from every corner of the cannabis community. Additional Resources * Pre-Register for CannMed 26 for just $100 (https://cvent.me/ryXrgZ) * CannMed Video Archive (https://cannmedevents.com/cannmed-video-archives/) * Connect with Mark on LinkedIn (https://www.linkedin.com/in/mark-scialdone-0247625b/) * The Dark Side of Cannabidiol (CBD): The Unanticipated Social and Clinical Implications of Synthetic Δ8-THC (https://pubmed.ncbi.nlm.nih.gov/36264171/) * Hash Church on YouTube (https://www.youtube.com/playlist?list=PL668WdsJxoe3m1XJPFCBQ2h4JUy8ulCLx) * CANN Delta-8-THC Panel Discussion (https://youtu.be/rdbQXLfKREg?si=Rrrk7gKpC4fH2ELJ) * GC Separation for Identification of iso-THC Contaminants and Accurate Quantification of Δ8 -THC and Δ9-THC in Cannabis Samples (https://www.caymanchem.com/literature/GC-Identification-of-iso-THC-Contaminants?srsltid=AfmBOoqiSA7-_N7g0lObACmVbGrCjyY3yrbCscyNkuDBws-o-_4-fId5)

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Ruth tell us her experience using larger doses of CBN and CBD to improve her sleep. In addition to regular use fo CBD for day to day ailments, Ruth discusses the many benefits of CBD. #cbn Derived from the cannabis plant, CBN is molecularly similar to THC, but is not psychoactive. It’s also less heavily regulated by the FDA. Previous research by Maher’s lab found that CBN had neuroprotective properties, but it wasn’t clear how it worked. Now, this new study explains the mechanism through which CBN protects brain cells from damage and death. Maher’s team looked at the process of oxytosis, also called ferroptosis, which is thought to occur in the aging brain. Growing evidence suggests that oxytosis may be a cause of Alzheimer’s disease. Oxytosis can be triggered by the gradual loss of an antioxidant called glutathione, causing neural cell damage and death via lipid oxidation. In the study, the scientists treated nerve cells with CBN, and then introduced an agent to stimulate oxidative damage. They further found that the CBN worked by protecting mitochondria, the cell’s powerhouses, within the neurons. In damaged cells, oxidation caused the mitochondria to curl up like donuts—a change that’s also been seen in aging cells taken from the brains of people with Alzheimer’s disease. Treating cells with CBN prevented the mitochondria from curling up and kept them functioning well. #cbdforpain This response creates anti-inflammatory and pain-relieving effects that help with pain management. This means that CBD oil and other products may benefit people with chronic pain, such as chronic back pain. Researchers applied CBD gel to rats for four days in a row. The rats received either 0.6, 3.1, 6.2, or 62.3 milligrams (mg) per day. The researchers noted reduced inflammation and overall pain in the rats’ affected joints. There were no obvious side effects.In addition, rats who received 62.3 mg/day had similar outcomes to the rats that received 6.2 mg/day. Receiving a substantially larger dosage didn’t result in them having less pain.The anti-inflammatory and pain-relieving effects of CBD gel could potentially help people with arthritis. #cbd Full-spectrum CBD is one of three main types of CBD and refers to products containing CBD alongside other active compounds found in the hemp plant, such as terpenes (a class of natural chemical compounds commonly found in plants), flavonoids (natural substances found in plants with anti-oxidative and anti-inflammatory properties) and other cannabinoids, including THC, says Dana Ohebshalom, registered nurse and owner of Hemp and Honey, a CBD and hemp store in Edgewater, New Jersey. CBD, including full-spectrum CBD, may interact with two receptors in the ECS—cannabinoid receptor 1 (CB1) in the central nervous system and cannabinoid receptor 2 (CB2) in the peripheral nervous system—resulting in a range of potential effects, such as pain reduction and anti-anxiety benefits. With sustained use, [some] evidence suggests CBD [may help] reduce the risk of certain types of cancer, seizures and neurological disorders and may improve heart and brain health conditions, too,” says Benjamin Caplan, M.D., a board-certified family medicine physician in Chestnut Hill, Massachusetts, and medical cannabis expert who specializes in helping patients with pain management at CED Clinic. Other potential benefits of full-spectrum CBD, according to Dr. Caplan, may include reduced anxiety and depression symptoms, improved sleep, pain alleviation, reduced inflammation, nausea and vomiting relief, and epileptic seizure management. #cbdforsleep Unfortunately, falling asleep or staying asleep can be difficult for certain types of sleepers. As many as 70% of Americans Trusted Source. National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. One increasingly popular strategy for sleeping better is taking cannabidiol (CBD), a derivative of cannabis. CBD is commonly used to improve sleep and decrease anxiety. Research shows that CBD has a calming effect on the nervous system Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. CBD can also alter mood because it affects the serotonin system. Outcomes vary among people and depend on the product type and dose. Unlike THC, CBD does not induce a feeling of being “high.” Even large doses of CBD do not produce THC-like effects. Additionally, a few studies have demonstrated that CBD reduces the psychoactive effects of THC. Studies of short-term CBD use show that patients do not experience withdrawal. https://www.healingessencecbd.com/ https://vimeo.com/healingessencecbd https://www.healingessencecbd.com/product/sesame-oil-capsules/

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I’m thrilled to be back with a brand-new season of The Joe Cohen Show! We’re kicking off the season with truly life-changing knowledge with a popular returning guest, Dr. Oz Garcia! In this episode, Dr. Oz Garcia and I explore the keys to happiness, the transformative power of meditation, and the world of biohacking for pain reduction and sleep optimization! We dive into the intricacies of mood, discussing all the different pathways that affect your overall mood and the different approaches to consider depending on your unique biology. Are you dependent on serotonin for improved mood? Is your GABA pathway the culprit for your bad days? What about the vagus nerve? Dr. Oz highlights how treatments are completely different based on your body's needs! As the conversation unfolds, you'll find yourself immersed in discussions about mood and pain, as Dr. Oz shares some of his secret supplements and lifestyle hacks that reduce his pain and allow him to continue doing all the physical activities that he loves. --------------- Socials & Websites: • SelfDecode: https://bit.ly/49xu7qE • The Joe Cohen Show: https://thejoecohenshow.com/ • Instagram: https://www.instagram.com/mrbiohacker/ • TikTok: https://www.tiktok.com/@thejoecohenshow • Twitter: https://twitter.com/thejoecohenshow Dr. Oz Garcia: • Website: https://ozgarcia.com/ • Instagram: https://www.instagram.com/ozwellness/ --------------- Timestamps: (0:16) - Meditation benefits & improving mood via supplements (27:13) - Vagus nerve stimulation (31:12) - What improved Dr. Oz Garcia's mood the most? (35:56) - Supplements for pain (47:04) - Happiness is different for everyone

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