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Are CBD and THC as effective as people believe — or is it mostly placebo? In this episode, we break down the latest clinical evidence on medical cannabis, exploring the real-world impact of CBD, THC, and cannabis-based therapies across conditions like cancer, chronic pain, anxiety, epilepsy, and more. With medical use on the rise globally, it’s time to separate hype from hard data. 🔍 We explore: - What randomized trials and meta-analyses actually say about effectiveness - Differences between THC and CBD in clinical use - Side effects, tolerability, and potential cognitive risks - How cannabinoids affect the brain, body, and mental health 📄 Scientific References: -Castle, R. D., Marzolf, J., Morris, M., & Bushell, W. C. (2025). Meta-analysis of medical cannabis outcomes and associations with cancer. Frontiers in Oncology, 15, 1490621. https://doi.org/10.3389/fonc.2025.1490621 - Sultan, S. R., Millar, S. A., England, T. J., & O’Sullivan, S. E. (2017). A systematic review and meta-analysis of the haemodynamic effects of cannabidiol. Frontiers in Pharmacology, 8, 81. https://doi.org/10.3389/fphar.2017.00081 - Batalla, A., Bos, J., Postma, A., & Bossong, M. G. (2021). The impact of cannabidiol on human brain function: A systematic review. Frontiers in Pharmacology, 11, 618184. https://doi.org/10.3389/fphar.2020.618184 - Leen, N. A., Kowal, M. A., Batalla, A., & Bossong, M. G. (2024). The effects of standardized cannabis products in healthy volunteers and patients: A systematic literature review. Frontiers in Pharmacology, 15, 1411631. https://doi.org/10.3389/fphar.2024.1411631 - Pagano, C., Navarra, G., Coppola, L., Avilia, G., Bifulco, M., & Laezza, C. (2022). Cannabinoids: Therapeutic use in clinical practice. International Journal of Molecular Sciences, 23(6), 3344. https://doi.org/10.3390/ijms23063344 - Pintori, N., Caria, F., De Luca, M. A., & Miliano, C. (2023). THC and CBD: Villain versus hero? Insights into adolescent exposure. International Journal of Molecular Sciences, 24(6), 5251. https://doi.org/10.3390/ijms24065251 - Borgan, F., Beck, K., Butler, E., McCutcheon, R., Veronese, M., Vernon, A., & Howes, O. D. (2019). The effects of cannabinoid 1 receptor compounds on memory: A meta-analysis and systematic review across species. Psychopharmacology. https://doi.org/10.1007/s00213-019-05283-3 - Stasiak, S. P., Hall, S. H., Nichols, J., Yaacoub, I., & Shelley, T. C. S. (2021). Examining the effects of cannabidiol (CBD) on anxiety and heart rate variability during acute stress: A randomized placebo-controlled trial. Psychopharmacology, 238(7), 1965–1977. https://doi.org/10.1007/s00213-021-05823-w - Lees, R., Hines, L. A., Hindocha, C., et al. (2023). Effect of four-week cannabidiol treatment on cognitive function: Secondary outcomes from a randomized clinical trial for cannabis use disorder. Psychopharmacology, 240(2), 337–346. https://doi.org/10.1007/s00213-022-06303-5 - Hoch, E., Hall, W., Friemel, C., et al. (2024). The risks and benefits of cannabis: A review of reviews. European Archives of Psychiatry and Clinical Neuroscience. https://doi.org/10.1007/s00406-024-01880-2 - Sarris, J., Sinclair, J., Karamacoska, D., Davidson, M., & Firth, J. (2020). Medicinal cannabis for psychiatric disorders: A clinically-focused systematic review. BMC Psychiatry, 20, 24. https://doi.org/10.1186/s12888-019-2409-8 - Bilbao, A., & Spanagel, R. (2022). Medical cannabinoids: A pharmacology-based systematic review and meta-analysis for all relevant medical indications. BMC Medicine, 20, 259. https://doi.org/10.1186/s12916-022-02459-1 - Lo, L. A., Lo, C. A., Pereira, C., et al. (2024). The acute effects of cannabidiol on cognitive and psychomotor performance: A systematic review and meta-analysis of human laboratory studies. Psychopharmacology. https://doi.org/10.1038/s41386-024-01847-w - Velayudhan, L., McGoohan, K., & Bhattacharyya, S. (2021). Evaluation of THC-related neuropsychiatric symptoms among adults aged 50 years and older: A systematic review and meta-regression analysis. JAMA Network Open, 4(2), e2035913. https://doi.org/10.1001/jamanetworkopen.2020.35913 🎧 Whether you're a clinician, patient, or just curious about cannabis, this episode brings nuanced, evidence-based insights to a frequently polarized topic. ⚠️ Disclaimer: This podcast summarizes peer-reviewed scientific research for informational and educational purposes only. It does not constitute medical advice. Always consult a licensed healthcare provider before starting or changing any medication, supplement, or treatment approach. 💡 Note: Content created with support from Google’s NotebookLM. The views expressed are those of the host and do not represent the original authors or their institutions. 🔔 Don’t forget to like, subscribe, and share if you find this episode helpful! #CBD #THC #MedicalCannabis #CannabisScience #ClinicalResearch #HealthFacts #EvidenceBased #SciencePodcast
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