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In this video, I'll explain marijuana metabolism. I'll show how our body processes and excretes marijuana and its metabolites. Possessing this knowledge is extremely important in your understanding of how to detox from marijuana. DELTA-9-THC or THC is the primary psychoactive ingredient of cannabis. When cannabis is smoked or vaporized, THC enters the bloodstream via absorption through the lungs. According to a research study, we inhale only about 50% of the THC from the joint. Approximately 30% of the THC is destroyed by heat. Other THC is lost through sidestream and incomplete absorption in the lungs. Therefore, only a part of inhaled THC reaches body circulation due to what is called the first-pass metabolism. Because of the first-pass metabolism only 25-30% of smoked THC is absorbed into the blood. Studies have shown that heavy users receive ~25% of the THC available for absorbtion while occasional users get ~12%, the reason being because heavy users smoke more efficiently. When ingested as edibles, THC enters the bloodstream through the walls of the stomach and intestines. Tests show that 90-95% of the THC then permeates the blood after ingestion. THC and some of its metabolites are fat-soluble. This means that they can dissolve in fats or oils. THC rapidly penetrates highly vascularized tissues such as the lungs, liver, heart, and body fat. About 70% of the THC is taken up by tissues, mostly by body fat. The THC is then slowly released back into the blood. Through this process, THC is continuously moving from the fat tissues into the blood and back again. Once in the blood, THC infiltrates the liver and undergoes 2 phases of metabolism. The CYP2C9 enzyme converts THC to 11-OH-THC in the first phase, after which CYP2C19 and CYP3A4 enzymes convert 11-OH-THC to 11-COOH-THC. THC metabolites are prepared for excretion in the second phase. UGT enzymes add a glucuronide molecule to metabolites through a process known as glucuronidation. 11-COOH-THC is metabolized mainly by the UGT1A3 enzyme and forms THC-COO-Gluc. 11-OH-THC is metabolized mainly by UGT1A9 and UGT1A10 enzymes and forms THC-O-Gluc. The resulting metabolites are soluble in water. Afterwards, they are dissolved in the bile and water and excreted with the urine and feces. In the intestines, bacterial enzymes 'remove' glucuronide from most of the THC metabolites. These metabolites are then reabsorbed back into the blood, where they can begin the entire cycle over again. This process is called enterohepatic circulation. One unfortunate aspect of this process is that only about 20% of THC metabolites are excreted with the urine, while 65% are excreted with the feces. Therefore, most of the THC metabolites will enter the enterohepatic recirculation and return into your blood. This is why detoxification from marijuana is such a lengthy process. Need to detox from weed? Here are the best THC(marijuana) Detox Kits to detox from weed and pass your drug test with flying colors. 👍🏻 Most effective THC detox kits for passing a drug test: 👍🏻👍🏻👍🏻 Fast Marijuana Detox Kit(extra strong): https://greenfleets.org/products/fast-thc-marijuana-detox-kit-extra-strong/?utm_source=youtube.com&utm_medium=referral&utm_campaign=weedmetabolism&utm_term=fastdetoxstrong 👍🏻👍🏻👍🏻 Green Fleets Premium 7-day THC Detox Kit: https://greenfleets.org/products/premium-detox-7-day-comprehensive-cleansing-program-p2706.html?utm_source=youtube.com&utm_medium=referral&utm_campaign=weedmetabolism&utm_term=gf7day 👩‍⚕️ The ultimate guide to passing a urine drug test: https://greenfleets.org/pass-drug-test/?utm_source=youtube.com&utm_medium=referral&utm_campaign=weedmetabolism&utm_term=detoxkits 😍 Subscribe to our channel if you want more information about the ways to detox and pass a drug test: http://www.youtube.com.com/c/ThcdetoxUsofficial Green Fleets has helped to pass a drug test for more than 50000 marijuana users. And each year, we continue to help more people to find a solution to pass urine, hair, and saliva drug tests for marijuana. We know that passing a pre-employment drug test can be very important for you. And it’s hard to find a trusted source of information. We get it! This is the reason we created Green Fleets. 😎 Visit our website for more in-depth information about ways to pass a drug test: https://greenfleets.org/?utm_source=youtube.com&utm_medium=referral&utm_campaign=weedmetabolism&utm_term=mainpage 0:00 Why it's important to understand marijuana metabolism 0:21 How much THC gets into the blood after smoking 1:18 How much THC gets into the blood after ingestion 1:32 How THC is stored in the body 2:10 Phase 1 of marijuana metabolism 2:34 Phase 2 of marijuana metabolism 3:15 Excretion of THC 3:26 Enterohepatic circulation of THC metabolites 4:07 How to speed up THC detoxification

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Are you going through menopause and struggling with symptoms like hot flashes, mood swings, and sleep problems? Discover how CBD oil, derived from the cannabis plant, can offer relief and improve your overall well-being during this transitional phase of life. CBD: check latest price and any current specials at https://healthiercbd.store/ In this video, we explore the benefits of CBD oil for managing menopause symptoms and delve into the scientific research behind its effectiveness. Join us as we uncover the potential of CBD oil to alleviate the challenges faced by women during menopause. Learn about a groundbreaking study published in the Journal of Cannabis Research that examined the impact of CBD oil on women experiencing menopause-related symptoms. The study involved 90 women who were randomly assigned to a CBD oil group or a placebo group. Discover the remarkable findings and the significant improvements reported by women using CBD oil, including enhanced sleep quality and reduced anxiety levels. Gain insights into the mechanism behind CBD oil's effectiveness by exploring its interaction with the body's endocannabinoid system, responsible for regulating crucial physiological functions such as sleep and mood. Find out how CBD oil's calming properties can help alleviate hot flashes and night sweats, providing much-needed relief from these uncomfortable symptoms. Menopause isn't just about physical changes; it also brings emotional challenges like mood swings and irritability. Discover how CBD oil's anxiolytic properties can help reduce anxiety and promote a sense of calm and relaxation, enhancing your emotional well-being during this transformative phase. Furthermore, explore the cognitive benefits of CBD oil, including its potential to combat brain fog and memory loss. Discover the fascinating studies that highlight CBD oil's ability to improve brain function and stimulate the growth of new brain cells. While CBD oil is not a cure for menopause, it can be a valuable addition to your self-care routine. Learn tips for choosing high-quality CBD oil, including the importance of third-party testing and starting with a low dose and gradually adjusting to find the right amount for you. Join us on this journey to explore the power of CBD oil in alleviating menopause symptoms and making your transition into this new phase of life a little smoother. Click the link in the description to find out more information, including pricing on top-quality US Made CBD oil. Don't let menopause symptoms hold you back. Discover how CBD oil can bring relief and support your well-being today! In this channel we share information about the benefits of CBD (cannabidiol) for various health conditions. Our goal is to provide education and insights into the use of CBD oil, cream, capsules, patches and other forms of CBD products to help with anxiety, depression, inflammation and other conditions. CBD is a natural compound found in hemp and marijuana plants. It has been gaining popularity as an alternative treatment for various health issues. Studies have shown that CBD can help with anxiety and depression by regulating the levels of serotonin and other neurotransmitters in the brain. It can also reduce inflammation by interacting with the body's endocannabinoid system. Our channel is dedicated to sharing relevant scientific research and studies on the benefits of CBD. We believe that it is important to base our content on factual information to help our viewers make informed decisions about their health. We provide information on different types of CBD products and their uses. For example, CBD oil can be used for pain relief, reducing anxiety and depression, and improving sleep quality. CBD cream can be applied topically to reduce inflammation and pain in specific areas of the body. CBD capsules and patches are also available for those who prefer a more convenient and discreet way of taking CBD. We welcome any questions or comments from our viewers and will try to answer them promptly. Our aim is to create a community of individuals who are interested in learning more about the benefits of CBD and how it can help improve their overall health and wellbeing. We hope that our videos will help educate and inform our viewers about the many benefits of CBD and how it can be used to improve their quality of life. Thank you for tuning in to our channel, and we look forward to sharing more information with you soon. #cbd #cbdformenopause #healthiercbd

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