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Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. https://www.instagram.com/totalsynthesis_official/ https://www.patreon.com/totalsynthesis https://www.total-synthesis.com This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
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Disclaimer: 21 and over only. If you are not 21 please close this video and do not subscribe to my channel. This Channel and all Cannabinoids Reviewed are in compliance with The Agriculture Improvement Act of 2018 (2018 Farm Bill). The Bill States "Any cannabinoid derived from hemp—defined as cannabis containing less than 0.3% delta-9 THC—was a legal product." My Channel is intended for Educational and Entertainment purposes Only. There is nothing for sale and I do not condone the use of any Cannabinoid I review. Speak to your Medical Physician for professional Cannabis Questions and concerns. Thank you Everyone for all the support and like always "BeSafeStayHigh
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CBD works to support your own body, so it does not inherently make you sleepy, but instead interacts with your own body's chemistry. If you take it in the evening, as your body is winding down, it can assist your body in preparing for sleep. Conversely, in the morning, as your body begins the process of waking up, it can assist there as well! If, at any point, you find yourself more tired than normal we recommend you work with our Dosage Support team to help adjust the timing of your dosage. Have more questions? Explore our blog & FAQ! Blog: https://myeq.com/blog/basics/how-to-use-cbd-to-aid-sleep/ FAQ: https://support.myeq.com/hc/en-us Website: http://www.myeq.com IG: https://www.instagram.com/equilibriawomen/ Facebook: https://www.facebook.com/equilibriawomen/
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