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Tags: Cannabis Research, Adverse Effects, CBD, Cannabis Adverse Events, CBD Side Effects, Medicine Kevin Spelman, PhD, MCPP, presents "Post-Marketing Surveillance of Full-Spectrum Hemp Extract CBD Products for Reported Adverse Events and Serious Adverse Events" at CannMed 23. 0:00 Intro 0:31 Disclosures 1:20 The Problem 2:08 The Solution 2:18 Methods Used 4:05 Phase I - Intake and Documentation of Original Incidents 5:06 Phase II - In Depth Review and Follow-up of Phase I Incidents 6:02 Phase III - Assessment of Strength of Association 7:23 Grades of Adverse Events 7:45 Dose Range 8:20 Results10:09 Summary of Adverse Events 11:30 Results continued 19:45 Previously Documented Adverse Events 20:21 Comparison of Adverse Events There is a paucity of data on the safety of hemp extracts in real-world use. While the number of clinical trials is building, the subject numbers are limited and conditions frequently do not mimic consumer use. Using a retrospective analysis of post-marketing surveillance data on full- spectrum hemp extract products (FSHE-Charlotte’s Web TM ) the frequency of adverse events (AEs) and serious adverse events (SAEs) of these products was assessed by analyzing AE reports and evaluating the total number of AEs against the total number of product units sold. From a total of approximately 1,939,172 product units sold during the 18-month period, 431 AEs were reported from 304 unique individuals, followed by a physician assessment. The incidence of AEs was 0.022% per unit sold. Seven AEs were classified as serious. The most common type of AEs reported were Grade 1 (CTCAE v5.0), and defined as asymptomatic or mild symptoms in the area of gastrointestinal (e.g. general abdominal discomfort) and nervous system disorders (e.g. dizziness/headache). Based on this dataset of spontaneous consumer reporting the FSHE products were determined to result in consumer reports of AEs (0.022%) and SAEs (0.00036%) and to be well tolerated at the recommended doses. These data, with the limitations of self- reports, are intended to be a starting point and we encourage more companies to explore post- marketing surveillance until more robust data are available. Learn More about CannMed: https://cannmedevents.com/

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Dr. Kimless presents four examples of cancer patients treated with low dose cannabis oil either as a sole treatment or in conjunction with conventional cancer therapies. Cannabis has been shown to play an important role in cancer treatment from mitigating treatment side effects to causing cancer cell apoptosis. Dosing is always a question, and these cases present successful treatments based on individual metrics using very lose doses of cannabinoids. All the CannMed 2017 video presentations can be viewed here: https://www.youtube.com/playlist?list=PLY7VMskICYhwFziqljzM7cHuyH4B6PP62 Debra Kimless, M.D. graduated magna cum laude from Muhlenberg College with a double major in Natural Sciences and Biology. She was selected to be part of Phi Beta Kappa honor society. She went on to medical school at Rutgers and residency at Temple University Hospital where she studied and became a clinical practitioner for over 15 years as a boarded Anesthesiologist with a subspecialty certification in Pain Medicine. Motivated by her mother who suffered horribly with intractable pain at the end of her life and who had always responded paradoxically to opiates, Dr. Kimless became a passionate champion for medical cannabis. Dr. Kimless dedicated the last several years to immersing herself in all aspects of medical cannabis, including scientific and medical applications for the treatment of patients. She has traveled the world studying under the most respected experts in cannabis medicine and science, most notably, in both the Netherlands and in Israel (two countries regarded as best practice models in the use of medical cannabis). She shares her knowledge by speaking with physicians to educate them about the endocannabinoid system and to help them understand how medical cannabis can be an effective tool to help patients. She also consults with patients pro bono to introduce cannabis medicine as a treatment option. She has first-hand experience in successfully treating patients with a variety of medical conditions using an individualized treatment plan. She collects patient data and has presented the case studies at national and international conferences and seminars. Her passion is to educate physicians, patients, and the public to de-stigmatize cannabis, so they understand that is a real and effective medical therapeutic choice.

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