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Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response (Preprint) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987002/ https://www.science.org/doi/10.1126/sciadv.abi6110 Cannabidiol (CBD) Potential regulator of the host stress and antiviral inflammatory responses (cannabinoid class of natural products) Hemp, cannabis plants, Less than 0.3% psychotropic tetrahydrocannabinol (THC) Oral solution of CBD is a U.S. FDA approved drug High-purity CBD inhibits SARS-CoV-2 replication in human lung epithelial cells Pretreated human lung cells (with ACE2 receptor) for 2 hours with CBD before infection with SARS-CoV-2. CBD potently inhibited viral replication under nontoxic conditions (no toxicity was observed at the effective doses) Worked in other human lung cell lines, worked in monkey kidney cells Tested on Wuhan strain and 3 VOCs Their ability to infect cells was comparably inhibited by CBD CBD or other cannabinoids? Checked 97 to 100% pure using quantitative nuclear magnetic resonance (qNMR). No toxicity was observed for any of the CBD preparations at the doses used to inhibit viral infection The CBD metabolite 7-OH-CBD, 7-hydroxy-cannabidiol exhibits antiviral activity Others did not work Combining CBD with THC (1:1) significantly suppressed CBD efficacy, consistent with competitive inhibition by THC. CBD and 7-OH-CBD metabolite are the active and equipotent ingredients for the treatment of epilepsy CBD acts at an early step after viral entry into cells CBD targets host cell processes. CBD inhibits viral RNA expression and reverses viral-induced changes in host gene expression CBD effectively eradicated viral RNA expression in the host cells Prevents changes in the cell produced by the virus to force the cell to produce new viral particles CBD induces strong activation of genes associated with the host stress response. Together, these results suggest that CBD acts to prevent viral protein translation and associated cellular changes. Induction of viral genes for spike, envelope, and nucleocapsid proteins is reduced ~99% with CBD CBD induction of increased transcription of 3 defensive endoplasmic reticulum genes CBD induces interferon expression as part of its antiviral activity CBD suppress viral infection, and promote degradation of viral RNA (SARS-CoV-2 infection suppresses the interferon signaling pathway) CBD sufficiently lowers the effective viral titer to enable normal host activation of the interferon pathway. CBD effectively reversed viral induction of cytokines that can lead to deadly cytokine storm CBD treatment significantly inhibits SARS-CoV-2 replication in mice After viral the challenge, administration of CBD continued twice daily for an additional 4 days CBD treatment significantly inhibited viral replication in lungs and nasal turbinates at day 5 after infection Lower dose of CBD reduced viral load by 4.8-fold in lungs Higher dose of CBD reduced viral load by 40 -fold in lungs During this period, the mice showed no signs of clinical disease These results establish the preclinical efficacy of CBD as an antiviral drug for SARS-CoV-2 during early stages of infection. CBD is negatively associated with indications of SARS-CoV-2 infection in patient medical records Given that high-purity CBD preparations are taken by a large number of individuals, we examined whether CBD prescriptions are associated with indications of SARS-CoV-2 infection An oral solution of CBD (100 mg/ml) (CBD100) is often used for the treatment of seizures Analysis of 1,212 patients Matched to control group counterparts 6.2% (75 patients) with CDB 8.9% for non-CBD patients (P = 0.014) Odds ratio (OR) of 0.65, (P = 0.009) Odds ratio (OR) of 0.48, (P = 0.006) Potential of Cannabidiol for the Treatment of Viral Hepatitis https://scholar.google.com/scholar_lookup?title=Potential+of+cannabidiol+for+the+treatment+of+viral+hepatitis&author=H.+I.+Lowe&author=N.+J.+Toyang&author=W.+McLaughlin&publication_year=2017&journal=Pharm.+Res.&pages=116-118 CBD inhibited HCV replication by 86.4% (Not Hep B) Other RNA viral infections Common cold Influenza SARS / MERS Dengue Hep C and E Ebola Rabies Polio Mumps Measles
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Hemp gummies have been gaining popularity in recent years as a natural, tasty, and convenient way to enjoy the health benefits of hemp. These gummies are made from the seeds of the hemp plant, which are rich in nutrients and have been used for centuries for their health-promoting properties. Let’s explore the nutritional powerhouse that is hemp gummies and discover the many ways they can benefit your health.
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In addition to protein, hemp seeds are also rich in healthy fats, particularly omega-3 and omega-6 fatty acids. These fats are important for brain health, reducing inflammation, and maintaining healthy skin and hair. Hemp seeds also contain high levels of vitamins and minerals, including vitamin E, magnesium, phosphorus, and potassium.
Furthermore, hemp seeds are a good source of fiber, which aids in digestion and helps promote a healthy gut microbiome. Fiber can also help regulate blood sugar levels and reduce the risk of heart disease. Overall, hemp seeds are a nutrient-dense superfood that can support your overall health and well-being.
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One of the most convenient ways to enjoy the health benefits of hemp seeds is through hemp gummies. These tasty treats are easy to take on the go and can be enjoyed anytime, anywhere. Hemp gummies are a great alternative for those who do not enjoy the taste of hemp seeds or who are looking for a more enjoyable way to incorporate them into their diet.
Not only are hemp gummies delicious, but they also provide a convenient way to get a daily dose of essential nutrients. Whether you’re looking to boost your protein intake, increase your omega-3 fatty acid consumption, or simply enjoy a healthy snack, hemp gummies can help you achieve your nutritional goals.
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How to Choose the Best Hemp Gummies
When choosing hemp gummies, it’s important to look for products that are made with high-quality ingredients and are free from artificial additives and preservatives. Opt for gummies that are made from organic hemp seeds and are free from GMOs, pesticides, and other harmful chemicals.
It’s also a good idea to check the label for the percentage of hemp seed oil in the gummies. Look for products that contain a high concentration of hemp seed oil to ensure you are getting the maximum nutritional benefits. Additionally, consider the flavor and texture of the gummies to ensure they are enjoyable to eat.
Lastly, consider the dosage of hemp gummies and follow the recommended serving size. Start with a low dose and gradually increase as needed to achieve the desired health benefits. By choosing high-quality hemp gummies and following proper dosing guidelines, you can enjoy all the nutritional benefits that hemp has to offer.
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There are many easy and delicious ways to incorporate hemp gummies into your daily routine. Enjoy them as a snack between meals, add them to your favorite recipes for a nutritional boost, or take them with you on-the-go for a quick and convenient source of nutrients. Hemp gummies are a versatile and tasty option for anyone looking to improve their health through diet.
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You can also use hemp gummies as a natural remedy for various health conditions, such as anxiety, stress, and inflammation. Hemp seeds contain compounds that have been shown to have antioxidant and anti-inflammatory properties, making them a great option for supporting overall health and well-being. By incorporating hemp gummies into your daily routine, you can enjoy the many benefits of this nutritional powerhouse.
Overall, hemp gummies are a delicious and convenient way to enjoy the health benefits of hemp seeds. Whether you’re looking to boost your protein intake, support brain health, or simply enjoy a tasty treat, hemp gummies are a versatile and nutritious option. Consider adding hemp gummies to your daily routine to experience all the benefits that this superfood has to offer.
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