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This is a recording of an Industrial Sonomechanics (ISM)' live webinar event from May 13th, 2020. The presentation was made by ISM's president and Chief Scientific Officer, Dr. Alexey Peshkovsky. Key Takeaways: 1. Achieving efficient, reproducible and predictable absorption of cannabinoids into the bloodstream has been and continues to be a major obstacle in the industry. 2.Traditional and historical methods of introducing cannabis into the body have been unpredictable in terms of bioavailability, timely onset of action and safety. 3. Cannabis extracts are NOT soluble in water, therefore, edibles and similar products taken by the mouth are slow and inefficient. 4. Translucent nanoemulsions of cannabinoids solve for these deficiencies, creating a rapid, predictable and reproducible effect. 5. High-intensity ultrasound has proven to be a superior solution for producing translucent nanoemulsions that can be infused into beverages without changing their appearance. Abstract: Oral administration of cannabinoids (e.g., as edibles or gel-caps), while safer and more discreet than smoking or vaping, suffers from low bioavailability, delayed onset of action and poor reproducibility. Being insoluble in water, cannabinoids cannot undergo gastrointestinal absorption until they are incorporated into mixed micelles, which are slowly formed in the small intestine during hydrolysis of co-administered triglycerides. While this step is necessary to allow cannabinoids to migrate to the intestinal absorptive cells, it drastically delays and diminishes the efficiency and reproducibility of the absorption process. Pharmaceutical industry's most successful method for overcoming similar challenges is to formulate hydrophobic bio-actives as oil-in-water nanoemulsions, which are kinetically stable, known to provide exceptional therapeutic effects, and allow bio-actives to be absorbed rapidly and completely. This presentation will demonstrate how the same approach can be applied to the cannabis industry. Commercial-scale production of translucent cannabinoid nanoemulsions (“water-soluble” CBD and THC) requires the use of an optimized formulation and a high-intensity ultrasonic processor, resulting in stable concentrates that are readily infused into and administered as beverages without compromising their appearance (e.g., optical clarity). Since aqueous dispersions of droplets in translucent nanoemulsions closely mimic mixed micelles, they rapidly migrate to the intestinal absorptive cells, avoiding the slow in-situ micelle formation process. Preclinical pharmacokinetic study results will be presented, showing significant onset of action acceleration and bioavailability enhancement of THC administered as a translucent nanoemulsion-infused beverage. Website: https://sonomechanics.com Blog: http://blog.sonomechanics.com/blog Facebook: https://www.facebook.com/industrial.sonomechanics/ Instagram: https://www.instagram.com/industrial_sonomechanics/ Twitter: https://twitter.com/sonomechanics LinkedIn: https://www.linkedin.com/company/industrial-sonomechanics-llc/
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When experiencing nausea, whether it be due to motion sickness, chemotherapy, pregnancy, or another cause, finding relief is essential for improving overall well-being. Antiemetics are a class of medications specifically designed to alleviate nausea and vomiting, allowing individuals to feel more comfortable and function normally. Understanding how antiemetics work, their role in controlling nausea, and their effectiveness is crucial for those seeking relief from these distressing symptoms.
How Do Antiemetics Work?
Antiemetics work by targeting various receptors in the body that trigger the sensation of nausea and vomiting. These receptors may be located in the brain, the gastrointestinal tract, or the inner ear, depending on the underlying cause of the nausea. By blocking these receptors or altering the signals they send, antiemetics can help prevent or reduce feelings of nausea and the urge to vomit.
One common type of antiemetic is known as a serotonin antagonist, which works by blocking serotonin receptors in the brain and gastrointestinal tract. Serotonin is a neurotransmitter that plays a key role in regulating mood, behavior, and, importantly, nausea. By blocking serotonin receptors, these medications can help reduce feelings of nausea and prevent vomiting.
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Another type of antiemetic targets dopamine receptors in the brain. Dopamine is another neurotransmitter that plays a role in regulating nausea and vomiting. By blocking dopamine receptors, these medications can help alleviate nausea and prevent the urge to vomit. This type of antiemetic is often used to manage nausea and vomiting caused by chemotherapy or certain medical conditions.
Types of Antiemetics
There are several different types of antiemetics available, each of which targets specific receptors or mechanisms involved in nausea. Serotonin antagonists, such as ondansetron and granisetron, are commonly used to prevent and treat nausea and vomiting associated with chemotherapy and surgery. Dopamine antagonists, such as metoclopramide and prochlorperazine, are often used to manage nausea and vomiting caused by medications or medical conditions.
Antihistamines, such as dimenhydrinate and meclizine, are commonly used to prevent and treat motion sickness. These medications work by blocking histamine receptors in the inner ear and brain, helping to reduce feelings of nausea and vertigo associated with motion sickness. Anticholinergic medications, such as scopolamine, are also effective in preventing motion sickness by blocking the action of acetylcholine, another neurotransmitter involved in nausea.
Effectiveness of Antiemetics
Overall, antiemetics are highly effective in controlling nausea and preventing vomiting in a wide range of situations. Studies have shown that these medications can significantly reduce the frequency and severity of nausea and vomiting, improving quality of life for individuals experiencing these symptoms. The effectiveness of antiemetics may vary depending on the underlying cause of the nausea, the specific medication used, and individual factors such as age, weight, and overall health.
It is important to work closely with a healthcare provider to determine the most appropriate antiemetic for your specific situation. Your doctor can help you identify the underlying cause of your nausea, prescribe the most effective medication, and adjust the dosage as needed to achieve optimal relief. In some cases, a combination of different types of antiemetics may be necessary to effectively control nausea and vomiting.
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