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Miniatury filmów zostały wykonane samodzielnie przez autora niniejszego kanału lub pobrane na zasadzie CC0 (Creative Commons Zero) z domen publicznych i w żaden sposób nie naruszają niczyich praw autorskich. Olej z nasion konopii to żółtobrązowa oleista ciecz, o orzechowym i lekko gorzkim smaku, pozbawiona substancji psychoaktywnych, zawierająca głównie kwasy omega-6 – kwas linolenowy 50%, kwasy omega-3 – kwas alfa-linolenowy – 15-20%, kwas gamma-linolenowy 5%, kwas oleinowy, tokoferole, prowitamina A, fitosterole, fosfolipidy, oraz bioflawonoidy. Jest to niewątpliwie bardzo dobry dodatek do racjonalnej diety, uzupełniający niedobory NNKT. Stosowany jest ponadto w kosmetologii i dermatologii. Olej RSO jest stężonym, gęstym, brązowozielonym ekstraktem a kwiatostanów konopii, zawierającym THC delta-9-tetrahydrokannabinol w stężeniu od 70 do 90% oraz CBD kanabidiol w stężeniu poniżej 2%. Jest otrzymywany w procesie ekstrakcji alkoholem izopropylowym, eterem lub benzyną. Nie jest zarejestrowany jako lek. Olej ten działa na receptory głównie CBR1, w mniejszym stopniu na receptory CBR2. W Polsce nielegalny. Olej CBD zawiera CBD o stężeniu od 4 do 15% oraz THC w stężeniu poniżej 0,2%. Wyprodukowany z konopi siewnej Canabis sativa. Nie posiada właściwości psychoaktywnych. Oprócz CBD, w skład oleju wchodzą inne kannabinoidy, CBC, CBN, CBG. Olej ten działa głównie na receptory TRPV1, TRPV2 oraz GRP55. THC jako substancja psychoaktywna może prowadzić do uzależnienia psychicznego i fizycznego, zmian nastroju, spadku poziomu inteligencji oraz powstawania psychoz i napadów leku, zaburzeń funkcjonowania układu wegetatywnego. W Polsce jest legalny. Istnieją badania potwierdzające działanie olejów RSO i CBD antynowotworowe na linie komórkowe raka jelita grubego, piersi, prostaty i glejaków. Ponadto w lecznictwie pozaonkologicznym olej RSO może działać przeciwbólowo, przeciwspastycznie oraz przeciwpadaczkowo w chorobach neurologicznych, zwłaszcza w stwardnieniu rozsianym. Nie ma żadnych badań klinicznych potwierdzających skuteczność tych olejów w leczeniu raka, więc nie można takiej skuteczności potwierdzić, ale nie można też wykluczyć. Niewątpliwie, nie zostały ustalone skuteczne i bezpieczne dawki oleju RSO i THC leczeniu onkologicznym, nie wiadomo tez nic o efektach długoterminowych leczenia olejem RSO, w tym przede wszystkim nie zbadano zjawiska lekooporności oraz spadku wrażliwości desensytyzacji receptorów kannabinoidowych - „down regulation”. Oleje zwierające CBD i THC powinny być wprowadzone do lecznictwa zamkniętego w leczeniu pacjentów onkologicznych, głównie w leczeniu przewlekłego, silnego bólu nowotworowego, chorób neurodegeneracyjnych oraz nowotworów. Jednocześnie powinny być prowadzone badania kliniczne nad skutecznością, działaniem oraz bezpieczeństwem stosowania tych związków. Piśmiennictwo: 1. Guindon, Josée, and Andrea G. Hohmann. "British journal of pharmacology”: 2011 1447-1463. 2. Pisanti, Simona, and Maurizio Bifulco. Pharmacological Research: 2009, 107-116. 3. Svíženská, Ivana, Petr Dubový, and Alexandra Šulcová. Pharmacology Biochemistry and Behavior: 2008, 501-511. 4. Mackie, K. Journal of neuroendocrinology, 2008, 10-14. 5. Alvheim, Anita R., et al. Obesity: 2012, 1984-1994.
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