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🎧 Follow our Spotify playlists: http://bit.ly/7cloudsSpotify 🎵 David Guetta - Titanium (Lyrics) ft. Sia ⏬ Download / Stream: https://davidguetta.lnk.to/Album7AY 🔔 Turn on notifications to stay updated with new uploads! 👉 David Guetta: http://facebook.com/DavidGuetta http://www.twitter.com/DavidGuetta http://www.davidguetta.com http://instagram.com/davidguetta ⭐️7clouds: https://open.spotify.com/user/7cloudsmusic https://instagram.com/7cloudsmusic/ https://facebook.com/7cloudsmusic https://twitter.com/7cloudsmusic ......... 🎤 Lyrics: David Guetta - Titanium ft. Sia [Verse 1] You shout it out, but I can't hear a word you say I'm talking loud, not saying much I'm criticized, but all your bullets ricochet You shoot me down, but I get up [Pre-Chorus] I'm bulletproof, nothing to lose Fire away, fire away Ricochet, you take your aim Fire away, fire away [Chorus] You shoot me down, but I won't fall I am titanium You shoot me down, but I won't fall I am titanium [Bass] [Verse 2] Cut me down, but it's you who'll have further to fall Ghost town and haunted love Raise your voice, sticks and stones may break my bones I'm talking loud, not saying much [Pre-Chorus] I'm bulletproof, nothing to lose Fire away, fire away Ricochet, you take your aim Fire away, fire away [Chorus] You shoot me down, but I won't fall I am titanium You shoot me down, but I won't fall I am titanium I am titanium I am titanium [Bass] [Bridge] Stone hard, machine gun Fired at the ones who run Stone hard, as bulletproof glass [Chorus] You shoot me down, but I won't fall I am titanium You shoot me down, but I won't fall I am titanium You shoot me down, but I won't fall I am titanium You shoot me down, but I won't fall I am titanium I am titanium ......... 📷 Wallpaper: https://unsplash.com/ ......... 📧Contact: [email protected] ......... #DavidGuetta #Titanium #Lyrics
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How Many CBD Gummies Should I Eat? Original Post: https://www.newphaseblends.com/how-many-cbd-gummies-should-i-eat/ New Phase Blends CBD Store: https://www.newphaseblends.com I get this question all the time. Is there a common CBD dosage amount? How much CBD does it take to work? A good rule of thumb is to follow the recommendations on the packaging of your product. Exceeding these recommendations is not advised. TLDR: Use about .25mg of CBD per bodyweight to achieve your intended results. At night, you can consider using a little bit more. CBD gummies are popular, because they work. However, you need to know proper dosing. How is CBD gummy dosing determined, though? You need to take into account your body weight, the mg of CBD (amount of CBD) in the CBD gummies, and your tolerance for the CBD gummies. Let’s find out below how to figure all of this out. What Is CBD? CBD is a compound (also known as Cannabidiol) derived from Hemp, which is a member of the cannabis plant family. These compounds are classified as cannabinoids. Of over 480 different compounds present in the plant, only around 124 are termed cannabinoids. The most infamous of these compounds is delta-9-tetrahydrocannabinol (Δ9-THC), which is the primary psychoactive ingredient in cannabis. If you haven’t been in a coma for the last 100 years, you’ve heard of THC. Industrial Hemp and marijuana are two different plants within the cannabis plant species. Marijuana contains high amounts of THC, while hemp typically contains high amounts of CBD, and almost no THC. In fact, hemp contains such a small amount of THC that there are no psychoactive effects. In order for CBD products, like CBD gummies, to be legal, they must come from hemp. CBD may also come from marijuana, but it will have high amounts of THC – and require the possession of a medical marijuana card. On the other hand, you can go buy CBD gummies online, or in a store, right now if you wanted. Essentially, although hemp and CBD has been around for thousands of years, we are only recently figuring out the true benefits of CBD. CBD gummies are only one form of CBD. CBD oil (aka CBD drops) is another popular form. Whether it’s gummies, or CBD oil, or any other CBD edible, you need to know the right dosage, though, before you take CBD gummies. Now that we know something about how and why CBD works, lets explore effective CBD dosing. To date, its effective dose in different disease states remains unclear. Why is this? Simply put, not enough longitudinal studies have been conducted. CBD, more specifically hemp, only recently became federally legal with the passing of the 2018 Farm Bill. Now that it’s not a controlled substance, quality studies are starting to come out. The problem is that CBD has so much potential that researchers simply can’t keep up with the demand for research. The benefits of CBD are definitely real, we just need more time to finish proper peer reviewed studies. First, consider the variations of treatment pathways: oral (CBD gummies/ CBD oil), topical, and sub-lingual. When you eat CBD, you likely need more than when applying it to your skin. This is because your digestive system destroys a lot of the nutrients you eat – including CBD. Your bodyweight will determine how much CBD you need. For example, a heavier person will likely need to eat more CBD than someone who does not weight as much. This is pretty normal across all medications and supplements – not just CBD gummies. Consider using about .25mg of CBD per pound of body weight at a time. For example, if I weigh 200 pounds, I would take 50mg of CBD gummies per dosage of CBD. This is typically a great starting point for most people. Pay attention to the number of gummies you eat, too. One gummy may only come in 25mg form. In this instance, you would need to eat two CBD gummies for the intended effect (25mg x 2 = 50mg). As a general rule of thumb, the more your body weight, the most CBD you may need. Next figure out what prompted you to eat a CBD gummy to being with. Is it pain reduction you are after? Maybe you need help sleeping. Is your anxiety sky rocketing lately? There are popular reasons people turn to CBD gummies. Large scale sleep studies using CBD are finally becoming mainstream. A good example comes out of the Permanente Journal in January of 2019. The doses used in this study were 25 mg/day to 175 mg/day. The results were extremely promising, with 79% of the study group reporting better sleep and decreased anxiety at the conclusion of the three 3 month trial. ALWAYS consult with a doctor if you are going to supplement or discontinue your current medication with/for CBD. Due to how CBD binds with different receptors, the effects of whatever you’re taking CBD with could be magnified. Only buy products with a scannable QR code. Without this you will have no idea what the dose of CBD you are putting into your body is.
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Parkinson’s disease, also known as PD, is the second most common neurodegenerative disorder. The disease is characterized by a loss of dopamine-producing neurons in the substantia nigra, which is an area of the brain responsible for movement. Cannabis, specifically CBD, has shown promise in treating some of the symptoms of PD. In this video we will define Parkinson’s disease and cannabis, explain how cannabis can help with PD, and physician perspectives on prescribing cannabis. This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program Copyright McMaster University 2021 For more information visit: https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm Time Stamps: Introduction/What is Parkinson’s Disease? → 00:00 - 01:23 What is Cannabis? → 01:24 - 02:34 How Can Cannabis Help With Parkinson’s? → 02:35 - 05:09 Physician Perspectives → 05:10 - 07:19 Conclusion → 07:20 - 07:52 References: Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson's disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95. Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376. Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243. de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535. Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418. Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556. Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417. Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376. Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457. Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143. Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21. Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21. Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884 Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010 Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/. Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111 Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. Journal of Forensic Sciences, 62(3), 602–611. https://doi.org/10.1111/1556-4029.13341
