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Is Big Pharma really healing us — or profiting from keeping us sick? NYT best-selling author Johann Hari (Stolen Focus, Lost Connections, Chasing the Scream, Magic Pill) returns with a powerful breakdown of the real causes of depression, anxiety, and the global attention crisis. Johann Hari reveals why only 2 of the 9 causes of depression are biological, exposing how Big Pharma, social media addiction, and modern lifestyle traps are fueling mental health issues. He dives into the dark rise of GLP-1 drugs (like Ozempic) and society’s toxic beauty obsession, while uncovering the overlooked role of sleep, community, and social connection in healing. Hari shares his personal experience with antidepressants, and explores how childhood shame and trauma drive addiction, weight gain, and despair. You’ll learn why even pets are being diagnosed with ADHD, what Silicon Valley insiders confessed about attention-hacking technology, and how our loss of focus is sabotaging relationships, careers, and democracy itself. If you’re ready to challenge the myths of mental health, regain your focus, and take back control of your mind, don’t miss this eye-opening conversation with Johann Hari. --- CHAPTERS: 00:00 - Intro 06:36 - New GLP-1 Weight Loss Drug Reflections 16:21 - Ties Between Childhood Trauma, Weight Gain, Depression, & Addiction 21:10 - Medication for Emotional Distress 34:50 - The Grief Loophole 40:06 - Biology of Trauma 49:54 - Do Antidepressants Work? 53:18 - Social Prescribing Benefits 57:15 - Political Solutions to Depression 1:05:24 - ADHD Epidemic 1:18:39 - How Social Media is Designed to Monopolize Your Attention 1:25:24 - Responsibility of Big Tech 1:30:28 - Food & Attention Connection --- Follow us on Substack for Exclusive Bonus Content: https://bialikbreakdown.substack.com/ Listen on our website: https://www.bialikbreakdown.com Listen on Spotify: https://open.spotify.com/show/6TgOe2poCdpZtQwKetQmU1 Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/mayim-bialiks-breakdown/id1546456269 Check out our Merch: https://shop.bialikbreakdown.com/ Sign up for our Newsletter: https://www.bialikbreakdown.com Follow us on Instagram: https://www.instagram.com/bialikbreakdown/ Find Mayim Bialik: https://mayimbialik.substack.com/ https://www.facebook.com/MissMayim/ https://www.twitter.com/MissMayim/ https://www.instagram.com/MissMayim/ https://www.tiktok.com/@mayimbialik Find Johann Hari: Twitter: https://www.twitter.com/johannhari101 Instagram: https://www.instagram.com/johann.hari Check out all of Johann Hari's Books: https://johannhari.com/ Our first episode with Johann Hari: https://youtu.be/JKFuI96biDU If interested in partnerships please contact [email protected] Theme Song Written, Produced, and Performed by Ed Robertson. Mixed by Kenny Luong. #MayimBialik #BialikBreakdown #JohannHari #Journalist #Journalism #GLP1 #Ozempic #Wegovy #WeightLoss #BodyImage #BodyPositivity #SocietyandCulture #Depression #Anxiety #Focus #ADHD #ADD #Attention #AttentionDeficit #BigPharma #Prozac #Zoloft #Lexapro #Antidepressants #Sleep #Medication #SocialConnection #Shame #Trauma #PTSD #EmotionalEating #ChildhoodTrauma #Addiction #WeightGain #WeightLossJourney #Despair #SiliconValley #TechAddiction #SocialMedia #SocialMediaAddiction #Technology #Democracy #Relationships #Love #Polarization #PoliticalDiscourse #Serotonin #LostConnection #Therapy # #Neurodivergence #Healing #Wellness
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Weight loss is a common goal for many individuals looking to improve their overall health and well-being. While diet and exercise are typically the go-to methods for shedding unwanted pounds, some people may struggle to see significant results despite their best efforts. In these cases, medications such as semaglutide can be a helpful tool in achieving weight loss goals. But what exactly does semaglutide do to facilitate weight loss?
How does semaglutide work to promote weight loss?
Semaglutide is a medication that belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs work by mimicking the effects of GLP-1, a hormone that is naturally produced in the body in response to food intake. GLP-1 helps to regulate blood sugar levels by stimulating insulin secretion and reducing the production of glucagon, another hormone that raises blood sugar. In addition to its effects on blood sugar, GLP-1 also plays a role in regulating appetite and food intake.
When semaglutide is taken, it activates the GLP-1 receptors in the body, leading to increased insulin secretion, reduced glucagon production, and a decrease in appetite. By regulating these processes, semaglutide helps to lower blood sugar levels, control cravings, and promote a feeling of fullness after meals. This can lead to a reduction in overall calorie intake, which in turn can result in weight loss.
In addition to its effects on insulin and appetite regulation, semaglutide has also been shown to slow down the emptying of the stomach, which can further contribute to feelings of satiety and reduce the urge to overeat. This delayed gastric emptying can help to prolong the feeling of fullness after meals, making it easier for individuals to stick to their weight loss goals by reducing the temptation to snack or consume large portions.
What are the benefits of using semaglutide for weight loss?
One of the main benefits of using semaglutide for weight loss is its ability to target multiple aspects of the body’s physiology that influence weight regulation. By targeting insulin secretion, glucagon production, appetite, and gastric emptying, semaglutide provides a comprehensive approach to weight loss that can be more effective than diet and exercise alone for some individuals.
Another benefit of semaglutide is its convenience as a once-weekly injection. This can be especially helpful for individuals who may struggle to adhere to daily medication regimens or who find it difficult to remember to take pills multiple times a day. The simplicity of a once-weekly injection can make it easier for people to incorporate semaglutide into their routine and stay on track with their weight loss goals.
Furthermore, semaglutide has been shown to be effective in promoting weight loss even in individuals who have struggled to lose weight with other methods. This can be particularly encouraging for individuals who have faced challenges in the past in achieving and maintaining a healthy weight. Semaglutide offers a new option for these individuals to jumpstart their weight loss journey and make lasting changes to their health and well-being.
Are there any potential side effects of using semaglutide for weight loss?
Like any medication, semaglutide is not without potential side effects. Some common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild and tend to improve over time as the body adjusts to the medication. In some cases, adjusting the dose of semaglutide or taking the medication with food can help to reduce these side effects.
In rare cases, more serious side effects may occur, such as pancreatitis or gallbladder problems. These side effects are more uncommon but can be serious and require medical attention. It’s important to discuss any concerns about potential side effects with a healthcare provider before starting semaglutide or any other weight loss medication.
Overall, the benefits of semaglutide for weight loss often outweigh the potential risks, especially for individuals who have struggled to lose weight through diet and exercise alone. By working with a healthcare provider to monitor for any potential side effects and adjust the medication as needed, individuals can safely and effectively use semaglutide to support their weight loss efforts.
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