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Struggling to lose weight despite a healthy lifestyle? In this episode, holistic nutritionist Nat Niddam joins us to uncover the science and strategy behind GLP-1 weight-loss peptides. We explore their transformative potential—not just for weight loss, but for enhancing insulin sensitivity, reducing inflammation, and curbing emotional eating. Nat shares expert tips for avoiding muscle loss, navigating metabolic plateaus, and using GLP-1s as part of a holistic health plan. Whether you're navigating menopause, managing PCOS, or looking for sustainable weight loss solutions, this conversation is packed with essential advice for achieving your optimal body composition. #GLP1 #WeightLossPeptides #MetabolicHealth #FatLossJourney #MidlifeWeightLoss #healthyweightloss 👇 FREE GLP-1 MINI COURSE 👇 Instant access to my training on weight-loss peptides—discover top strategies for body recomposition, optimal dosing, and hormone balancing to safely reach your goals! 🚀 https://www.optimizedwomen.com/courses/glp-1 🚀 🔑 KEY TOPICS 🔑 -The role of GLP-1 peptides in managing weight loss resistance and enhancing insulin sensitivity. -Why muscle loss is a concern when using GLP-1s—and how to prevent it with nutrition and resistance training. -The importance of a holistic approach: addressing hormone imbalances, gut health, and nutrient deficiencies. -Practical ways to reset your body’s weight set point and achieve long-lasting results. -Complementary peptides and supplements to support your body during GLP-1 use. -Strategies for managing common side effects like constipation and reflux. 🕐 TIMESTAMPS 🕐 [00:00] Introduction & Overview of GLP-1s for Weight Loss [02:51] Nat Niddam’s Approach to Holistic Nutrition & Peptide Therapy [05:00] Common Mistakes When Using GLP-1s [08:55] Why Testing Is Crucial Before Starting Peptides [12:30] The Importance of Protein Intake for Preserving Muscle [15:45] Resistance Training & Preventing Sarcopenia [19:25] How GLP-1s Impact Appetite and Food Cravings [21:40] Addressing Common Side Effects: Reflux and Constipation [24:24] Supporting the Liver, Thyroid, and Adrenals During Peptide Use [28:29] Nat’s Personal GLP-1 Journey and Lessons Learned [36:00] Overcoming Metabolic Plateaus [38:40] Complementary Peptides: BPC-157, CJC-1295, and More [43:10] Next-Generation Weight Loss Peptides and Future Innovations [48:30] The Role of Digestive Health in Weight Loss Success [52:27] Measuring Progress Beyond the Scale: Body Composition Insights [54:09] Nat’s Top Three Tips for Living an Optimized Life 🎙️ GUEST 🎙️ Guest: Nat Niddam Website: https://www.natniddam.com Instagram: https://www.instagram.com/nathalieniddam 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Podcast Links: https://linktr.ee/optimizedwomen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen 👇 FREE GLP-1 MINI COURSE 👇 Instant access to my training on weight-loss peptides—discover top strategies for body recomposition, optimal dosing, and hormone balancing to safely reach your goals! 🚀 https://www.optimizedwomen.com/courses/glp-1 🚀 ⭐️⭐️⭐️⭐️⭐️ Enjoying the podcast? Don’t forget to subscribe and leave a review to help spread the word! 🎵 MUSIC CREDIT 🎵 "Power Play" by Top Flow (https://pixabay.com/users/top-flow-28521292) Licensed under Pixabay License (https://pixabay.com/service/terms)
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Time stamps 0:30 what are ketones The 3 ketone bodies are acetone, acetoacetate and beta hydroxybutyrate Your liver makes ketones from acetyl-CoA 1:02 why does breath smell weird on keto (keto breath) 1:43 what is beta hydroxybutyrate (the best ketone for brain health) 1:55 how are ketones made (ketogenesis) Ketogenesis is the pathway that makes ketones, ketogenesis happens in your liver only Long chain fatty acids are oxidized in the mitochondria to yield acetyl-CoA (beta oxidation) In a ketogenic state / keto metabolic state the acetyl-coa is favourably directed into ketogenesis instead of the tricarboxylic acid / citric acid cycle Under normal conditions (normal carbohydrate diet / fed) the long chain fatty acids are oxidized to acetyl-coa and the acetyl-coa will then enter the tricarboxylic acid / citric acid cycle In starvation states or proper keto diets, if the TCA cycle is slowed or deplete of intermediates then the acetyl-coa enters ketogenesis Ketogenesis should only happen in extreme starvation or on true keto diets 3:13 ketogenic pathway biochemistry Enzymes essential to ketogenesis… Thiolase, HMG-CoA synthase, HMG-CoA lyase, acetoacetate decarboxylase, betahydroxybutyrate dehydrogenase 4:47 acetoacetate can be cleaved to give CO2, acetone and betahydroxybutyrate 5:37 what is BHB 6:46 how do ketones give you energy (metabolism basics) Acetyl-coa is the common entry point to the tricarboxylic acid / citric acid cycle - glucose, fatty acids and amino acids can all be metabolized into ACoA ACoA can enter the TCA cycle for complete oxidation and to yield large amounts of energy Ketogenesis is when you make ketones from ACoA in the liver, the ketones then enter circulation, travel to the brain where they are converted back into ACoA, now in your brain the ACoA enters the TCA cycle for complete and rapid oxidation thus yielding large amounts of energy 9:02 How to get into ketosis / when are you in ketosis 9:37 what happens when you are starving 10:39 what is keto diet Keto diet macro distribution 5% calories from carbohydrate 25% calories from protein 70% calories from fat 11:12 why is starvation bad for you (protein sparing effect / TCA cycle depletion) 11:59 long term fasting / prolonged fasting diets 13:40 ketosis acidifies your blood and damages organs (ketoacidosis)
