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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt
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How to lose body fat without losing muscle is something many people strive for in the gym. Only do the most important factors when trying to lose weight is making sure you are in a consistent caloric deficit. This means you are eating fewer calories than your body burns. The other two biggest things are making sure you are including a solid strength training program as well as a structured cardio program. Cardio alone does not burn fat. It is the combination of diet and exercise( strength training and cardio) that will help you lose body fat and see the results you want to see. #fatloss #weightloss #fitnesstips #cardio #strengthtraining
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In recent years, the ketogenic diet has gained popularity for its numerous health benefits, including weight loss, increased energy, and improved mental clarity. As a result, the market for keto supplements has exploded, with countless products claiming to help users achieve ketosis and reap the rewards of a keto lifestyle. One such product that has caught the attention of consumers and investors alike is Keto One, which was featured on the hit TV show Shark Tank. In this article, we will explore how Keto One stands out in the crowded keto supplement market, what sets it apart from its competitors, and why it has garnered so much attention.
The Science Behind Keto One
Keto One is a keto supplement that is designed to help users achieve and maintain ketosis – a metabolic state in which the body burns fat for fuel instead of carbohydrates. The key ingredient in Keto One is beta-hydroxybutyrate (BHB) ketones, which are exogenous ketones that can help expedite the process of getting into ketosis. BHB ketones have been shown to increase energy levels, suppress appetite, and enhance mental focus, making them a popular choice for those following a ketogenic diet.
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Additionally, Keto One contains other natural ingredients such as MCT oil, green tea extract, and apple cider vinegar, all of which have been shown to support weight loss and promote overall health. By combining these ingredients in a unique and potent formula, Keto One provides users with a powerful tool for reaching their health and fitness goals.
One of the key factors that sets Keto One apart from other keto supplements on the market is its emphasis on quality and purity. The makers of Keto One source only the highest quality ingredients, ensuring that each batch is free from fillers, additives, and artificial ingredients. This commitment to quality not only sets Keto One apart from its competitors but also ensures that users are getting a safe and effective product.
The Benefits of Keto One
There are numerous benefits to using Keto One as part of a ketogenic diet or weight loss regimen. One of the primary advantages of Keto One is its ability to help users get into ketosis faster and stay there longer. By providing the body with a source of exogenous ketones, Keto One can help jumpstart the process of fat burning and accelerate weight loss. Additionally, Keto One can help curb cravings and reduce hunger, making it easier for users to stick to their diet and achieve their goals.
Another benefit of Keto One is its ability to boost energy levels and enhance mental clarity. Many users report feeling more focused and alert when taking Keto One, making it an ideal supplement for those looking to improve their cognitive function and productivity. Additionally, the natural ingredients in Keto One can help support overall health and well-being, making it a versatile and beneficial addition to any wellness routine.
For those looking to improve their physical performance, Keto One can also be a valuable tool. By providing the body with a source of clean energy in the form of ketones, Keto One can help enhance endurance, strength, and recovery, making it a popular choice among athletes and fitness enthusiasts. Whether you are looking to lose weight, boost energy, or improve your athletic performance, Keto One can help you achieve your goals and reach your full potential.
Why Choose Keto One?
With so many keto supplements on the market, you may be wondering why you should choose Keto One over the competition. One of the main reasons to choose Keto One is its proven track record of success. Keto One has helped thousands of users achieve their health and fitness goals, with many reporting significant weight loss, increased energy, and improved overall well-being. By choosing Keto One, you can feel confident that you are investing in a product that has been tried and tested by real people and proven to deliver results.
Additionally, Keto One is backed by a team of experts who are dedicated to helping users succeed on their keto journey. The makers of Keto One are passionate about health and wellness and are committed to providing users with the support and resources they need to reach their goals. From personalized meal plans to expert tips and advice, the team behind Keto One is there to guide you every step of the way and ensure that you get the most out of your keto experience.
Finally, Keto One is a transparent and trustworthy brand that prioritizes customer satisfaction above all else. The makers of Keto One are upfront about their ingredients, sourcing practices, and manufacturing processes, ensuring that users know exactly what they are putting into their bodies. With Keto One, you can feel confident that you are getting a high-quality product that is safe, effective, and designed to help you succeed.
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Weight loss can be a challenging journey for many, but with the right approach, it can become more manageable and even accelerated. One popular method that has gained traction in recent years is the ketogenic diet, or keto for short. This high-fat, low-carb diet has been shown to help individuals shed excess weight and improve overall health. In addition to keto, another key player in the weight loss game is apple cider vinegar (ACV). When combined, keto and ACV form a powerful duo that can help you reach your weight loss goals faster and more effectively.
The Keto Diet
The keto diet is a high-fat, low-carb eating plan that focuses on consuming healthy fats, moderate proteins, and minimal carbohydrates. By drastically reducing your carb intake and replacing it with fats, your body enters a state of ketosis, where it burns fat for fuel instead of glucose. This shift in metabolism can lead to rapid weight loss and numerous health benefits, including improved insulin sensitivity, increased energy levels, and enhanced mental clarity.
One of the key principles of the keto diet is to prioritize whole, nutrient-dense foods and avoid processed and refined products. This means focusing on foods like avocados, nuts, seeds, fatty fish, and non-starchy vegetables while steering clear of sugar-laden snacks, grains, and high-carb fruits.
Many individuals have experienced significant weight loss and improvements in various health markers, such as cholesterol levels and blood sugar control, while following the keto diet. It’s essential to consult with a healthcare professional before making any drastic changes to your eating habits, especially if you have pre-existing health conditions.
Apple Cider Vinegar Benefits
Apple cider vinegar (ACV) has been used for centuries for its potent health properties, including aiding in weight loss. ACV is made by fermenting apple cider with yeast and bacteria, resulting in a vinegar rich in acetic acid and other beneficial compounds. When consumed, ACV can help regulate blood sugar levels, improve digestion, and promote feelings of fullness – all of which can support weight loss efforts.
One of the most well-known benefits of ACV is its ability to enhance satiety, or feelings of fullness, which can help reduce overall calorie intake and support weight loss. Research suggests that acetic acid, the main component of ACV, may also help boost metabolism, increase fat burning, and reduce fat storage in the body.
In addition to its weight loss benefits, ACV has been shown to have antimicrobial and antioxidant properties, which can help support overall health and well-being. Incorporating ACV into your daily routine can be as simple as mixing a tablespoon or two with water or using it as a salad dressing or marinade.
The Power of Keto & ACV Combined
When combined, the keto diet and apple cider vinegar can complement each other and amplify the effects of weight loss. By following a ketogenic eating plan that emphasizes healthy fats and minimizes carbohydrates, you can put your body in a state of ketosis, where it becomes efficient at burning fat for fuel.
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Adding apple cider vinegar to your daily routine can further enhance the weight loss process by promoting feelings of fullness, regulating blood sugar levels, and supporting digestion. The acetic acid in ACV can help optimize digestion and nutrient absorption, making it easier for your body to break down fats and proteins and utilize them for energy.
It’s important to note that while the keto diet and ACV can be beneficial for weight loss, they are not magic bullets and should be used in conjunction with a balanced diet and regular physical activity. As with any diet or supplement, it’s essential to listen to your body, monitor your progress, and make adjustments as needed to achieve sustainable results.
Conclusion
In conclusion, combining the ketogenic diet with apple cider vinegar can be a powerful strategy for accelerating weight loss and improving overall health. By following a high-fat, low-carb eating plan and incorporating ACV into your daily routine, you can optimize your metabolism, enhance feelings of fullness, and support digestion – all of which can lead to more effective and sustainable weight loss.
Remember, weight loss is a journey that requires patience, consistency, and dedication. Be sure to consult with a healthcare professional before making any significant changes to your diet or lifestyle, and listen to your body’s cues to ensure that you are on the right path to achieving your goals. With the right tools and mindset, you can achieve lasting success in your weight loss journey with the power of keto and ACV.
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How ozempic and loss drugs truly affect your body – the hidden truth revealed In this must-watch video, we dive deep into how weight loss drugs like Ozempic, Wegovy, and Mounjaro really work inside your body. These popular injections are making headlines in the US, but what's the truth behind the hype? We reveal the science, side effects, real results, and the hidden risks that most people don’t know. If you're considering using Ozempic or similar drugs, this video could change your perspective. In this video, you’ll discover: - What Ozempic really does to your body - The truth about GLP-1 weight loss drugs - The side effects no one talks about - Is the weight loss permanent or temporary? - Shocking long-term health risks - Natural and safer alternatives you can explore Before you inject — watch this! Your health matters. Get the facts and make an informed choice. Subscribe now for more truthful health insights, expert breakdowns, and trending wellness topics. 00:00 - What Happens to Your Body When You Take Ozempic? 00:29 - A New Era of Weight Loss: What is Ozempic? 00:59 - How Ozempic Works in the Body 01:27 - Benefits vs. Risks: Understanding Ozempic's Purpose 01:59 - Blood Sugar Control: Ozempic’s Primary Function 02:29 - Appetite Control: How Ozempic Helps You Eat Less 03:01 - Clinical Trials: Is Ozempic Really Effective for Weight Loss? 03:30 - Consistent Results Across All Groups 04:04 - Side Effects: The Price of Slimness 04:34 - Serious Health Risks to Watch Out For 05:02 - Hypoglycemia Risk in Non-Diabetics 05:34 - Rebound Weight Gain After Stopping Ozempic 06:03 - Unknown Long-Term Effects and Ongoing Research 06:34 - Personalizing Your Approach: Is Ozempic Right for You? 07:03 - Weight Loss Isn’t One-Size-Fits-All 07:33 - The Bigger Picture: Ozempic in the Context of Health 08:01 - True Health Beyond the Scale #Ozempic #Weight loss drugs #USA health trends #weight loss journey #GLP1Drugs #Ozempic truth #Olimpic side effects #American health #Fat losstips #Viral health video 🔔𝐃𝐨𝐧'𝐭 𝐟𝐨𝐫𝐠𝐞𝐭 𝐭𝐨 𝐬𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝐭𝐨 𝐨𝐮𝐫 𝐜𝐡𝐚𝐧𝐧𝐞𝐥 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞 𝐮𝐩𝐝𝐚𝐭𝐞𝐬. https://www.youtube.com/@eliasdebebe/?sub_confirmation=1 🔗 Stay Connected With Us. Facebook: https://www.facebook.com/elias.debebe/ Instagram: https://www.instagram.com/debebeelias/ Tiktok (eliasdebebe4): https://www.tiktok.com/@eliasdebebe4 Tiktok (eliasdebebe): https://www.tiktok.com/@eliasdebebe249?lang=en Twitter (X): https://twitter.com/elio249 Linkedin: https://www.linkedin.com/in/elias-debebe/ Pinterest: https://www.pinterest.com/business/hub/ 📩 For business inquiries: [email protected] ============================= 🎬Suggested videos for you: ▶️ https://www.youtube.com/watch?v=YAERxesAkkE ▶️ https://www.youtube.com/watch?v=o5fBtHmqTp4 ▶️ https://www.youtube.com/watch?v=bSI1OUJJK9I ▶️ https://www.youtube.com/watch?v=HiQVApxnbDc ▶️ https://www.youtube.com/watch?v=tq-RpD6fCZY ▶️ https://www.youtube.com/watch?v=-xAcW2ETX2U ▶️ https://www.youtube.com/watch?v=kCEg0MmF4Gg ▶️ https://www.youtube.com/watch?v=njtFvTvatyo ▶️ https://www.youtube.com/watch?v=ScJK2VNrb2Y ▶️ https://www.youtube.com/watch?v=a_nxFghs73g ▶️ https://www.youtube.com/watch?v=2doQUKyhy_E ▶️ https://www.youtube.com/watch?v=HkdnsT2bKns ▶️ https://www.youtube.com/watch?v=TXeNgzHsILk ▶️ https://www.youtube.com/watch?v=XHjux7hX4KI ▶️ https://www.youtube.com/watch?v=fbJFFrSKBkI ================================= ✅ About elias debebe. Welcome to the elias debebe channel! Your ultimate guide to holistic wellness and sustainable weight loss starts here. Join us on a transformative journey to a healthier, happier you with expert insights into nutrition, fitness, and mindful eating. Discover science-backed advice, practical tips, and delicious recipes curated by a passionate team of nutritionists and fitness enthusiasts. We debunk myths, deliver motivational content, and provide tools to help you build a sustainable, nourishing lifestyle. 🔔 If you’re focused on holistic wellness and sustainable weight loss, hit subscribe! Stay tuned for expert insights, mindful eating tips, and healthy food ideas! https://www.youtube.com/@eliasdebebe/?sub_confirmation=1 ================================= Disclaimers: The content provided in this video is intended solely for educational and entertainment purposes. It is imperative to consult with a healthcare professional regarding your health requirements. Approach this video, as with all my review videos, as an educatio resource rather than personalized recommendations. It should not be used to self-diagnose and is not a substitute for a medical exam, cure, treatment, diagnosi prescription, or recommendation. Foster a positive environment in the comments section and promote kindness. A trigger warning is extended to those with disordered eating tendencies. Stay connected by subscribing to this channel and activating the notification bell to ensure you never miss out on future content!
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"Breaking: Weight Loss Medication Reduces Migraines by Half - GLP-1 Study" 🚨 BREAKING: New 2025 research reveals GLP-1 medications like Ozempic and Wegovy don't just help with weight loss - they're cutting migraine frequency by 50%! ✅ What you'll learn: How GLP-1 affects brain receptors for pain control Why weight loss drugs are reducing migraines Latest study findings from 2025 Dual benefits: weight management + migraine relief Important safety considerations 💊 Popular GLP-1 medications discussed: #Ozempic #Wegovy #Semaglutide #Tirzepatide #Mounjaro 🔬 This unexpected discovery is changing how doctors view GLP-1 therapy. If you suffer from both weight issues AND chronic migraines, this could be life-changing news. ⚠️ MEDICAL DISCLAIMER: This content is for educational purposes only. Always consult your healthcare provider before starting any medication. Individual results may vary. 📚 HealthToons Academy brings you the latest health breakthroughs explained simply. Subscribe for more medical updates! #GLP1 #WeightLoss #MigrainerelieF #HealthNews2025 #MedicalBreakthrough #DiabetesMedication #HealthTips #WellnessJourney #HealthToons #healthtips #usa
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Are you stuck on your weight loss journey and wondering why the scale isn’t moving? You’re not alone! In this video, I break down 10 common reasons why your weight loss has plateaued—and what you can do to start seeing results again. Whether it’s sneaky eating habits, a slowed metabolism, or just plain stress, I’m giving you real talk and practical tips to help you stay on track. If you’re over 50 and working toward a healthier lifestyle, this one’s especially for you! Subscribe for more wellness tips, midlife motivation, and real talk from your favorite Auntie. #WeightLossOver50 #MidlifeHealth #WeightLossPlateau #HealthyLifestyle #FitnessOver50 #WeightLossJourney #FatLossTips #WellnessWithAuntie #WomenOver50 #AntiAgingFitness #StalledWeightLoss #LoseWeightNaturally
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Chrissie Swan, a well-known Australian television and radio personality, has recently embarked on a weight loss journey using gummies. Her transformation has sparked a lot of interest and curiosity among her fans and followers. In this article, we will uncover Chrissie Swan’s weight loss journey with gummies and explore how this unconventional method has helped her achieve her health and fitness goals.
The Beginning of Chrissie Swan’s Weight Loss Journey
Chrissie Swan has always been open about her struggles with weight and body image. As a busy working mother, she found it challenging to prioritize her health and fitness. However, after years of yo-yo dieting and failed attempts at losing weight, Chrissie decided to take a different approach. She discovered gummies, a trendy new weight loss supplement that claimed to help curb cravings and boost metabolism.
At first, Chrissie was skeptical about trying yet another weight loss product. She had tried countless diets and supplements in the past, with little to no success. However, after doing some research and reading positive reviews from other users, Chrissie decided to give gummies a try. She was pleasantly surprised by the results and noticed a significant difference in her energy levels and overall well-being.
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Chrissie Swan’s weight loss journey with gummies started slowly but steadily. She incorporated the gummies into her daily routine, along with a balanced diet and regular exercise. With consistency and dedication, Chrissie began to see the pounds gradually melt away. Her fans and followers were amazed by her transformation and inspired by her determination to take control of her health.
The Impact of Chrissie Swan’s Weight Loss Journey
Chrissie Swan’s weight loss journey with gummies has had a profound impact on her life. Not only has she shed excess weight and improved her physical health, but she has also boosted her confidence and self-esteem. Chrissie now feels more comfortable in her own skin and radiates a sense of empowerment and positivity.
In addition to the physical benefits, Chrissie’s weight loss journey has also had a positive effect on her mental and emotional well-being. She no longer feels trapped by negative body image beliefs or societal expectations. Chrissie has learned to embrace her natural curves and imperfections, accepting herself for who she is and celebrating her unique beauty.
Chrissie Swan’s weight loss journey with gummies has inspired many others to take charge of their health and wellness. Her story serves as a reminder that transformation is possible, no matter how daunting the journey may seem. With determination, perseverance, and the right tools, anyone can achieve their fitness goals and lead a fulfilling, healthy life.
FAQs About Chrissie Swan’s Weight Loss Journey with Gummies
Q: Are gummies safe for weight loss?
A: Gummies can be a safe and effective supplement for weight loss when used in conjunction with a balanced diet and regular exercise. It’s essential to consult with a healthcare professional before starting any new weight loss regimen.
Q: How long did it take Chrissie Swan to see results with gummies?
A: Chrissie Swan began to see noticeable results within a few weeks of incorporating gummies into her routine. However, individual results may vary, and it’s important to be patient and consistent with any weight loss journey.
Q: Can anyone use gummies for weight loss?
A: While gummies are generally safe for most individuals, it’s crucial to check the ingredients and consult with a healthcare provider if you have any underlying health conditions or concerns. Pregnant or nursing women should avoid using gummies without medical advice.
