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CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety. TRANSCRIPT: CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own. CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood. CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy. REFERENCES: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250 McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944 Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041 World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf Special thanks to Srikar Gade for help with fact-checking this video.
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#cbd #cbn #cannabinoids These CBD gummies are combined with the powerful cannabinoid CBN perfect for self-soothing and winding down for the night and come in our delicious vegan cherry flavor. With 40mg of CBD and 20mg of CBN per gummy, we recommend starting with 1/4 gummy and working your way up from there. You can explore these gummies at: https://www.restartcbd.com/product/cbn-cbd-gummies/ And we do ship nationwide! ____________________ Voted the #1 Dispensary in Austin, Texas, RESTART CBD is an education-first craft cannabis brand. Founded by three sisters, we take the stigma out of using cannabis and offer a wide range of high-quality 3rd party tested products ranging from sublingual oils, edibles, hemp flower, vapes, topicals, pet treats, CBD, delta 8, delta 9, and more. Our mission is to help you Rethink Cannabis. We operate a brick-and-mortar in North Austin and are available 24/7 to shop at restartcbd.com where we ship nationwide. DISCLAIMER: This video has not been evaluated by the FDA and is not intended to provide medical advice. We are not doctors and everything we share is intended to be educational as a jumping off point for further research. We are also not legal professionals, so we are not giving legal advice, we are simply commenting our interpretation of the current regulations and legislation for educational purposes. Please consult with a doctor or lawyer if you have any specific concerns. Everything we promote is in relationship to the 2018 Farm Bill which legalized hemp up to .3% Delta 9 THC on a dry weight basis, therefore all our products are both federally and state compliant.
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André Barros conversa com Gregório Ventura, jornlista e fundador da Editora Vista Chinesa, que traz informação de qualidade sobre Cannabis em livros impressos e digitais. A política nacional sobre drogas: um novo paradigma. Participe do nosso debate em Brasília. https://sites.brasil247.com/politica-nacional-sobre-drogas-um-novo-paradigma/ Apoie o novo documentário da TV 247 em https://www.catarse.me/marceloarruda • Apoie o 247 em brasil247.com/apoio: https://www.brasil247.com/apoio • Você também pode fazer doação por Pix com a chave [email protected] ou fazer uma assinatura Pix em https://bit.ly/pix-247 e pode pedir sua nota fiscal em [email protected]. • Ao contrário da mídia corporativa, a TV 247 se financia por meio da sua própria comunidade. Você pode apoiar a TV 247 e o site Brasil 247 de diversas formas. Saiba como: • Cartão de crédito pela Vindi: https://bit.ly/assine-brasil247 • Boleto ou transferência bancária: email para [email protected] ou no link Vindi • Seja membro no Youtube: https://www.youtube.com/brasil247/join • Transferência pelo Paypal: https://bit.ly/PayPal_Brasil247 • Financiamento coletivo pelo Vakinha: http://vaka.me/1391967 • Financiamento coletivo pelo Catarse: https://www.catarse.me/brasil247 • Financiamento coletivo pelo APOIA.se: https://apoia.se/brasil247 • Financiamento coletivo pelo Patreon: https://www.patreon.com/brasil247 • Acesse o site Brasil 247: https://www.brasil247.com/ • Siga-nos no Twitter: https://twitter.com/brasil247 • Siga-nos no Facebook: https://www.facebook.com/brasil247 • Siga-nos no Instagram: https://instagram.com/brasil_247 • Receba nossa newsletter e fique por dentro do 247: https://landing.mailerlite.com/webforms/landing/g8f3o0 e toque no sininho para ativar as notificações. • Inscreva-se no nosso canal de vídeos curtos: http://bit.ly/cortes247 • Entre no nosso canal do Telegram: https://t.me/brasil247oficial #brasil247 #tv247 © Copyright - Editora 247 LTDA. Proibida a reprodução sem autorização prévia.
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